The acute respiratory distress syndrome (ARDS) is a critical illness characterized by severe
lung inflammation and pulmonary oedema caused by increased alveolar permeability …

The adenosine 5′-triphosphate-gated P2X4 receptor channel is a promising target in
neuroinflammatory disorders, but the ability to effectively target these receptors in models of …

Rationale: Two phenotypes of Acute respiratory distress syndrome (ARDS), which have
been termed Hypoinflammatory and Hyperinflammatory, have also been observed in …

Inflammatory conditions are associated with the extracellular release of nucleotides,
particularly ATP. In the extracellular compartment, ATP predominantly functions as a …

Abstract Treatment of acute lung injury (ALI) and its most severe form, acute respiratory
distress syndrome (ARDS), remain unsolved problems of intensive care medicine …

Signalling by extracellular ATP has become a focus of hot interest in virtually any field in
biomedical sciences, from developmental biology to neurophysiology, from kidney diseases …

Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse lung injury,
which results in increased pulmonary vascular permeability and loss of aerated lung tissue …

Abstract Extracellular adenosine 5'-triphosphate (ATP) acts as an autocrine and paracrine
agent, the actions of which on affected cells are mediated by P2 receptors (P2R), which …

Highlights•All immune cells express plasma membrane ion channels of the P2X
subfamily.•P2X channels are gated by ATP present in the inflammatory microenvironment.• …

Acute respiratory distress syndrome (ARDS) is a severe, often fatal, lung condition frequently
seen in patients in the ICU. ARDS is triggered by an inciting event such as pneumonia or …