Cancer has become the leading cause of human death in the world, due to its uncontrolled
and rapid proliferation properties. Radio and chemotherapy are used in the treatment of …

Purpose/Objective: Radiation therapy is an important therapeutic modality in the treatment of
several thoracic tumors. Though tumor control is best obtained with higher doses of …

Superoxide dismutases play an important role in human health and disease. Three decades
of effort have gone into synthesizing SOD mimics for clinical use. The result is the Mn …

Radiation therapy (RT) is an important therapeutic modality in the treatment of thoracic
tumors. The maximum doses to these tumors are often limited by the radiation tolerance of …

Exposure of cells to ionizing radiation leads to formation of reactive oxygen species, which
are associated with radiation-induced cytotoxicity. Therefore, compounds that scavenge …

Purpose: To determine whether administration of a catalytic antioxidant, Mn (III) tetrakis (N,
N′-diethylimidazolium-2-yl) porphyrin, AEOL 10150, with superoxide dismutase (SOD) …

Background: Metalloporphyrin antioxidants can protect tissues against radiation-induced
damage. However, for effective use in radiotherapy as normal tissue radioprotectants, they …

Purpose: We examined the effects of manganese (III) meso-tetrakis (diethyl-2-5-imidazole)
porphyrin, a metalloporphyrin antioxidant (MPA), on neural tissue radiation toxicity in vivo …

In the cell Mn porphyrins (MnPs) likely couple with cellular reductants which results in a drop
of total charge from 5+ to 4+ and dramatically increases their lipophilicity by up to three …

Results There was no significant difference in lung damage and immunohistochemistry
studies between the RT alone and RT+ AEOL10150 (2.5 mg/kg BID). Lung histology at 26 …