Synthetic antitumor lipids are metabolically stable lysophosphatidylcholine derivatives,
encompassing a class of non-mutagenic drugs that selectively target cancerous cells. In this …

Synthetic alkyl lipids, such as the ether lipids edelfosine (1-O-octadecyl-2-O-methyl-rac-
glycero-3-phosphocholine) and ohmline (1-O-hexadecyl-2-O-methyl-rac-glycero-3-β …

Modulation of membrane lipid composition and organization is currently developing as an
effective therapeutic strategy against a wide range of diseases, including cancer. This field …

Several studies have demonstrated interactions between the two leaflets in membrane
bilayers and the importance of specific lipid species for such interaction and membrane …

Synthetic alkylphospholipids (ALPs), such as edelfosine, miltefosine, perifosine,
erucylphosphocholine and erufosine, represent a relatively new class of structurally related …

Cell proliferation and metastasis are considered hallmarks of tumor progression. Therefore,
efforts have been made to develop novel anticancer drugs that inhibit both the proliferation …

The lipid bilayer is a functional component of cells, forming a stable platform for the initiation
of key biological processes, including cell signalling. There are distinct changes in the lipid …

Edelfosine (1-O-octadecyl-2-O-methyl-sn-glycero-phosphocholine) and miltefosine (
hexadecylphosphocholine) are synthetic alkylphospholipids (ALPs) that are reported to …

Cell expansion and metastasis are considered hallmarks of tumour progression. Therefore,
efforts have been made to develop novel anti‐cancer drugs that inhibit both the proliferation …

Synthetic anticancer alkylphospholipids (APLs), such as edelfosine, miltefosine and
perifosine, are a group of structurally related lipids that act on cellular membranes rather …