Background. The concept that a patient could develop cancer twice was first put forward by
Billroth. Second primary neoplasms are a particular feature of head and neck cancer …

Background The improvement in locoregional control of head and neck carcinomas over the
last decades does not appear to modify the final survival of these patients, mainly due to the …

Abstract Objective/Hypothesis: To investigate the impact of second primary tumors on
prognosis for patients with head and neck squamous cell carcinoma (HNSCC). Study …

This is a review on second primary tumors in patients with head and neck cancer. These
patients have a high risk of developing other cancers simultaneously or subsequently. The …

Multiple primary tumors are a known phenomenon in head and neck cancer. They are
partially responsible for the limited improvement in survival of head and neck cancer during …

The recognition of a second primary carcinoma in a patient with known head and neck
cancer is considered a poor prognostic sign. However, its true implication for patient survival …

Background. Patients with cancer of the oral cavity and pharynx have been described to be
particularly susceptible to the development of new cancers. Methods. Using data collected …

The development of second malignant tumors (SMTs), in patients who have had their first
tumor treated successfully, represents a serious limitation of current therapeutic strategies …

OBJECTIVE: Clinical study of second primary malignancies (SPM) in patients with cancer of
the head and neck (HNC). STUDY DESIGN AND SETTING: Retrospective study over 48 …

The overall survival of patients with head and neck squamous cell carcinoma (HNSCC) has
not improved dramatically in recent decades despite the introduction of new surgical …