RNA-binding proteins are involved in various aspects of RNA metabolism such as
processing, translational control, stabilization, localization and transport. Many of these …

The past year has been significant advances in our understanding of the mechanism of RNA
movement between the nucleus and the cytoplasm. The emerging view is that proteins bind …

The subcellular localization of RNAs correlates with their function and how they are
regulated. Most protein-coding mRNAs are exported into the cytoplasm for protein synthesis …

Our understanding of protein export from the nucleus to the cytoplasm has been advanced
recently by the discovery of active, signal-mediated export pathways. Nuclear export signals …

RNA export from the nucleus is thought to be linked to proper processing and packaging into
ribonucleoprotein protein complexes. A system to observe mRNA nuclear export in living …

In eukaryotes, the separation of translation from transcription by the nuclear envelope
enables mRNA modifications such as capping, splicing, and polyadenylation. These …

Is There a Spatial Component to Nuclear RNA Processing and Transport? A controversial
model holds that the RNA processing machinery resides at defined locations in the nucleus …

The majority of the mammalian genome is transcribed by RNA polymerase II, yielding a vast
amount of noncoding RNA (ncRNA) in addition to the standard production of mRNA. The …

Eukaryotes are divided into two major compartments: the nucleus where RNA is synthesized
and processed, and the cytoplasm, where mRNA is translated into proteins. Although many …

Over the past decade, various studies have indicated that most of the eukaryotic genome is
transcribed at some level. The pervasiveness of transcription might seem surprising when …