Δ9-Tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells

G Galanti, T Fisher, I Kventsel, J Shoham… - Acta …, 2008 - Taylor & Francis
Background. The active components of Cannabis sativa L., Cannabinoids, traditionally used
in the field of cancer for alleviation of pain, nausea, wasting and improvement of well-being …

Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival

JP Marcu, RT Christian, D Lau, AJ Zielinski… - Molecular cancer …, 2010 - AACR
Abstract The cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor agonist Δ9-
tetrahydrocannabinol (THC) has been shown to be a broad-range inhibitor of cancer in …

[HTML][HTML] THC reduces ki67-immunoreactive cells derived from human primary glioblastoma in a GPR55-dependent manner

MR Kolbe, T Hohmann, U Hohmann, C Ghadban… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma (GBM) is the most frequent primary brain tumor entity with
poor prognosis and resistance to current standard therapies. Cannabinoids, such as …

Effects of tetrahydrocannabinols on human oral cancer cell proliferation, apoptosis, autophagy, oxidative stress, and DNA damage

A Semlali, S Beji, I Ajala, M Rouabhia - Archives of Oral Biology, 2021 - Elsevier
Abstract Objective Cannabinoids, including delta-8-and delta-9-tetrahydrocannabinol (THC)
have a palliative care impact and may therefore be beneficial against cancer. The aim of this …

The cannabinoid δ9‐tetrahydrocannabinol inhibits RAS‐MAPK and PI3K‐AKT survival signalling and induces BAD‐mediated apoptosis in colorectal cancer cells

A Greenhough, HA Patsos, AC Williams… - … journal of cancer, 2007 - Wiley Online Library
Deregulation of cell survival pathways and resistance to apoptosis are widely accepted to be
fundamental aspects of tumorigenesis. As in many tumours, the aberrant growth and survival …

[HTML][HTML] Cannabinoids as anticancer drugs: current status of preclinical research

B Hinz, R Ramer - British journal of cancer, 2022 - nature.com
Drugs that target the endocannabinoid system are of interest as pharmacological options to
combat cancer and to improve the life quality of cancer patients. From this perspective …

Δ9-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling

S Takeda, S Yamaori, E Motoya, T Matsunaga… - Toxicology, 2008 - Elsevier
We recently reported that Δ9-tetrahydrocannabinol (Δ9-THC) has the ability to stimulate the
proliferation of human breast carcinoma MCF-7 cells. However, the mechanism of action …

Cannabinoids and gliomas

G Velasco, A Carracedo, C Blázquez, M Lorente… - Molecular …, 2007 - Springer
Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking
endogenous substances—the endocannabinoids—that activate specific cell surface …

Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo

A Preet, RK Ganju, JE Groopman - Oncogene, 2008 - nature.com
Abstract Δ 9-Tetrahydrocannabinol (THC) is the primary cannabinoid of marijuana and has
been shown to either potentiate or inhibit tumor growth, depending on the type of cancer and …

[HTML][HTML] Cannabis biomolecule effects on cancer cells and cancer stem cells: Cytotoxic, anti-proliferative, and anti-migratory activities

H Peeri, H Koltai - Biomolecules, 2022 - mdpi.com
Cancer is a complex family of diseases affecting millions of people worldwide. Gliomas are
primary brain tumors that account for~ 80% of all malignant brain tumors. Glioblastoma …