Individually, metabolic variations can significantly influence predisposition to obesity in the
form of the obesity-prone (super-responders) and obesity-resistant (non-responders) …

Obesity-resistant (non-responder, NR) phenotypes that exhibit reduced susceptibility to
developing obesity despite being exposed to high dietary fat are crucial in exploring the …

Objectives: The aim of this study was to explore the phenotypic differences underpinning
obesity susceptibility or resistance based on the metabolic and transcriptional profiling of …

Abstract Background Divergently selected Lean and Fat mouse lines represent unique
models for a polygenic form of resistance and susceptibility to obesity development …

Poly-unsaturated fatty acids (PUFAs) are considered to be healthier than saturated fatty
acids (SFAs), but others postulate that especially the ratio of omega-6 to omega-3 PUFAs …

Obesity-prone (OP) rodents are used as models of human obesity predisposition. The goal
of the present study was to identify preexisting defects in energy expenditure components in …

We determined whether altered physical activity levels might underlie the contrasting
adiposity of a divergently selected polygenic murine model of metabolic syndrome (Fat; F) …

Individuals exhibit a great variation in their body weight (BW) gain response to a high fat
diet. Identification of predictive factors would enable better directed intervention toward …

Although obesity rates are rapidly rising, caloric restriction remains one of the few safe
therapies. Here we tested the hypothesis that obesity-associated disorders are caused by …

Among outbred Sprague-Dawley rats, approximately one-half develop diet-induced obesity
(DIO) and one-half are diet resistant (DR) on a diet relatively high in fat and energy content …