Genomes across a wide range of eukaryotic organisms fold into higher-order chromatin
domains. Topologically associating domains (TADs) were originally discovered empirically …

A current question in the high-order organization of chromatin is whether topologically
associating domains (TADs) are distinct from other hierarchical chromatin domains …

INTRODUCTION Chromatin adopts an intricate three-dimensional (3D) organization in the
nucleus that is critical for many genome processes, from gene regulation to genome …

Metazoan genomes are highly organized inside the cell nucleus. Topologically associating
domains (TADs) represent the building blocks of genome organization, but their linear …

Background Chromatin folding gives rise to structural elements among which are clusters of
densely interacting DNA regions termed topologically associating domains (TADs). TADs …

Mammalian chromosomes fold into arrays of megabase‐sized topologically associating
domains (TAD s), which are arranged into compartments spanning multiple megabases of …

Chromosome conformation capture and orthologous methods uncovered the spatial
organization of metazoan chromosomes into autonomously folded substructures, often …

Recent advances enabled by the Hi-C technique have unraveled many principles of
chromosomal folding that were subsequently linked to disease and gene regulation. In …

Understanding the mechanisms that underlie chromosome folding within cell nuclei is
essential to determine the relationship between genome structure and function. The recent …

Understanding how regulatory sequences interact in the context of chromosomal
architecture is a central challenge in biology. Chromosome conformation capture revealed …