Effect of various interferons on the spontaneous cytotoxicity exerted by lymphocytes from normal and tumor-bearing patients

MA Lucero, WH Fridman, MA Provost, C Billardon… - Cancer Research, 1981 - AACR
Natural killer cell activity, which represents the spontaneous cytotoxicity of lymphocytes
toward tumor cells, has been measured in 173 tumor-bearing patients and 25 healthy …

Influence of human interferon-α therapy on cytotoxic functions of blood lymphocytes: Studies on lectin-dependent cellular cytotoxicity, antibody-dependent cellular …

S Einhorn, H Blomgren, H Strander… - Cancer Immunology …, 1983 - Springer
Various cytotoxic functions of blood lymphocytes were studied in 101 patients undergoing
daily treatment with human interferon-α (IFN). Antibody-dependent cellular cytotoxicity and …

Natural cytotoxicity and interferon production in human cancer: deficient natural killer activity and normal interferon production in patients with advanced disease.

AS Kadish, AT Doyle, EH Steinhauer… - Journal of immunology …, 1981 - journals.aai.org
Natural cytotoxicity was measured in 51 adult patients with solid epithelial malignant tumors
and in 27 normal subjects. Peripheral blood leukocytes (PBL) from 31% of the patients and …

Depressed spontaneous natural killing and interferon augmentation in patients with malignant lymphoma

CM Hawrylowicz, RC Rees, BW Hancock… - European Journal of …, 1982 - Elsevier
Abstract A substantial proportion (44%) of peripheral blood lymphocyte samples from 41
patients with malignant lymphoma have been shown to have depressed or undetectable …

Modulation of target cell susceptibility to human natural killer cells by interferon

M Moore, WJ White, MR Potter - International Journal of Cancer, 1980 - Wiley Online Library
The spontaneous cytolytic activity of human peripheral blood lymphocytes in a short‐term
51chromium release assay was markedly enhanced by pretreatment with partially purified …

Antagonistic effects of interferons on the cytotoxicity mediated by natural killer cells.

G Trinchieri, D Santoli, D Granato… - Federation …, 1981 - europepmc.org
Human interferons (IFs) can induce a several-fold increase in the natural cytotoxicity of
human lymphocytes on target cell lines. IFs increase the efficiency of cytotoxicity and the …

Spontaneous cell-mediated cytotoxicity in humans: role of interferon and immunoglobulins

G Trinchieri, D Santoli, H Koprowski - The Journal of Immunology, 1978 - journals.aai.org
Human lymphocytes secrete high levels of interferon a few hours after being cultured with
certain tumorderived or virus-transformed cell lines. Interferon and interferon inducers (eg …

Interferon and spontaneous cytotoxicity in man. I. Enhancement of the spontaneous cytotoxicity of peripheral lymphocytes by human leukocyte interferon

S Einhorn, H Blomgren… - international Journal of …, 1978 - Wiley Online Library
A purified preparation of human leukocyte interferon used at this hospital in the treatment of
malignant diseases was tested for its ability to modify the spontaneous cytotoxicity of …

Decrease in the phagocytic activity of peripheral monocytes in patients treated with human interferon-α

S Einhorn, C Jarstrand - Cancer Immunology, Immunotherapy, 1982 - Springer
The influence of daily intramuscular injections of 3× 10 6 units of interferon-α (IFN-α) on the
phagocytic activity of peripheral monocytes was studied in 28 tumor patients. One day after …

Enhancement by interferon of lymphocyte cytotoxicity in normal individuals to cells of human lymphoblastoid lines

SV Skurkovich, AS Skorikova… - The Journal of …, 1978 - journals.aai.org
The cytotoxic activity of healthy donor lymphocytes toward cells of two human
lymphoblastoid lines was studied by radioimmunoassay with 51Cr. Cells of the following …