DIPG-86. INVESTIGATING THE TUMOR ENVIRONMENT AND SIGNALING DEPENDENCIES DRIVING DIFFUSE MIDLINE GLIOMA TUMOR INITIATION …

P Patel, S Ryall, B Kukreja, A Turinski… - Neuro …, 2024 - ncbi.nlm.nih.gov
BACKGROUND Diffuse Midline Glioma (DMG) is a incurable tumor affecting children.
Recent genomic investigations have identified a recurrent H3K27M mutation which induces …
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DIPG-06. FUNCTIONAL MULTI-OMIC PROFILING OF THE LANDSCAPE OF DIFFUSE MIDLINE GLIOMAS TO IDENTIFY THERAPEUTIC VULNERABILITIES

IJ Findlay, D Staudt, RJ Duchatel, ER Jackson… - Neuro …, 2024 - ncbi.nlm.nih.gov
BACKGROUND Diffuse midline glioma (DMG) is a devastating pediatric high-grade glioma
(pHGG) located along the midline structures of the brain and spine. Palliative radiotherapy is …
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Identification of Targetable Pathway Dependencies in Diffuse Midline Glioma

SG PARACKAL - bridges.monash.edu
Diffuse Midline Glioma (DMG), is a highly aggressive and infiltrative paediatric brain tumour
with currently no known cure. Characterisation of DMG has since revealed a diverse …
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[PDF] nature.com

Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies

IJ Findlay, GN De Iuliis, RJ Duchatel, ER Jackson… - Oncogene, 2022 - nature.com
Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …
被引用次数：60 相关文章 所有 7 个版本

DIPG-06. Uncovering the FACTs in Diffuse Midline Glioma (DMG)

H Holliday, A Ehteda, A Khan, B Krug… - Neuro …, 2022 - ncbi.nlm.nih.gov
Effective treatments are urgently needed for the incurable paediatric brainstem tumour
Diffuse Midline Glioma (DMG). Most DMGs contain Histone H3 mutations (H3K27M), which …
相关文章 所有 2 个版本
[PDF] springer.com

Global activation of oncogenic pathways underlies therapy resistance in diffuse midline glioma

MM Georgescu, MZ Islam, Y Li, ML Circu… - Acta Neuropathologica …, 2020 - Springer
Diffuse midline gliomas (DMGs) are aggressive pediatric brain tumors with dismal prognosis
due to therapy-resistant tumor growth and invasion. We performed the first integrated …
被引用次数：22 相关文章 所有 13 个版本

DIPG-11. DISSECTING THE DIFFUSE MIDLINE GLIOMA TUMOR MICROENVIRONMENT COMMUNICATIONS USING MULTI-OMICS APPROACHES

R Collot, CR Moreno, A Wezenaar, A Zomer… - Neuro …, 2023 - ncbi.nlm.nih.gov
Diffuse midline glioma (DMG) represents a highly aggressive pediatric brain tumor with no
chance of survival. Treatment options are urgently needed, and efforts have been put …
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Transcriptomic and Proteomic Spatial Profiling of Pediatric and Adult Diffuse Midline Glioma H3 K27-Altered, Reveals Region Specific Differences and Limited …

S Damodharan, JM Shireman, E Xie, E Distler… - europepmc.org
Diffuse midline glioma, H3 K27-altered (DMG-Alt) are highly aggressive malignancies of the
central nervous system (CNS) that primarily affect the pediatric population. Large scale …
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[PDF] oup.com

DIPG-57. A systems biology approach to defining and targeting master regulator dependencies from bulk and single-Cell RNA-seq in diffuse midline glioma (DMG)

EC Fernández, J Wang, A Griffin, H Minns… - Neuro …, 2022 - academic.oup.com
Diffuse midline glioma (DMG) are fatal pediatric brain tumors with no effective systemic
therapies. Molecular profiling demonstrates epigenetic dysregulation and heterogeneity …
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DIPG-55. DISSECTING THE ECOSYSTEM OF PEDIATRIC DIFFUSE MIDLINE GLIOMA

J Morscio, S Jacobs, F De Smet - Neuro-Oncology, 2024 - ncbi.nlm.nih.gov
BACKGROUND Pediatric gliomas are heterogeneous tumors encompassing high grade
(pHGG) and low grade (pLGG) subtypes. For tumors not amenable to surgery, in particular …
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