An high-pressure liquid chromatographic method was used to measure allopurinol and
oxipurinol in plasma and urine in 6 healthy volunteers after a single intravenous or oral dose …

A spectrophotometric assay for measuring allopurinol and oxipurinol has been developed
which can detect as little as 5× 10− 8 M of each in serum and urine. With this assay, serum …

Previous studies have described a pharmacokinetic interaction between probenecid, a
uricosuric drug, and oxipurinol, the major metabolite of allopurinol. In single dose studies, no …

Allopurinol is a widely used drug in the management of hyperuricaemia. It is rapidly and
extensively absorbed following oral administration. The major and active metabolite …

A method is described for allopurinol and oxipurinol assay within human plasma and urine
in the range expected during therapy. The method is based on high-performance ion …

Allopurinol is the drug most widely used to lower the blood concentrations of urate and,
therefore, to decrease the number of repeated attacks of gout. Allopurinol is rapidly and …

RESULTS A chromatogram obtained from blank plasma is shown in Fig. 1A. A
chromatogram from standard plasma (allopurinol and oxipurinol, 10 pg/ml of each) 8 in Fig …

Aims The prevalence of hyperuricaemia and gout increases with age as does the incidence
of adverse effects to allopurinol, the major uric acid lowering drug. The present study was …

1. Allopurinol usage in 50 patients of a city teaching hospital was surveyed. 2. The plasma
concentrations of oxipurinol and uric acid and the urinary production of uric acid were …

This study examined dosage prescribing patterns and steady-state oxipurinol plasma
concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) …