Intracellular accumulation of amyloid-β (Aβ) protein has been proposed as an early event in
AD pathogenesis. In patients with mild cognitive impairment, intraneuronal Aβ …

Extracellular amyloid β (Aβ) that confers neurotoxicity and modulates synaptic plasticity and
memory function has been central to the amyloid hypothesis of Alzheimer's disease (AD) …

Objective: The goal of this study was to investigate the role of endogenous amyloid‐β
peptide (Aβ) in healthy brain. Methods: Long‐term potentiation (LTP), a type of synaptic …

Alzheimer's disease (AD) is the leading type of dementia worldwide. Despite an increasing
burden of disease due to a rapidly aging population, there is still a lack of complete …

Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their
relationship to neurodegeneration and dementia remains controversial. In contrast, there is …

Despite of long-standing evidence that beta-amyloid (Aβ) peptides have detrimental effects
on synaptic function, the relationship between Aβ, synaptic and neuron loss is largely …

An early role of amyloid-β peptide (Aβ) aggregation in Alzheimer's disease pathogenesis is
well established. However, the contribution of intracellular or extracellular forms of Aβ to the …

Alzheimer's disease (AD) is the leading type of dementia worldwide. With an increasing
burden of an aging population coupled with the lack of any foreseeable cure, AD warrants …

Our previous research demonstrated that soluble amyloid-β (Aβ) 42, elicits presynaptic
glutamate release. We hypothesized that accumulation and deposition of Aβ altered …

Accumulation of intraneuronal amyloid-β peptide (Aβ) appears to be an early event in
Alzheimer's disease (AD), suggesting its important role in the neurodegenerative process of …