AIM: To investigate the effects of HIF-1α by RNAi on invasion and metastasis of esophageal
carcinoma Eca109 cells in vitro and in vivo, in order to explore its probable mechanism …

Abstract Hypoxia-inducible factor-1α (HIF-1α) has been found to enhance tumor invasion
and metastasis, but no study has reported its action in esophageal carcinoma. The goal of …

Background: In microenvironment of malignant tumors, Hypoxia-Inducible Factors (HIF),
most importantly HIF-1α, play an important role in regulation of adaptive biological response …

Objective To investigate the effects of HIF-1α on adhesion and invasion of human
nasopharyngeal carcinoma CNE-1 cells under hypoxia and underlying molecular …

Objective To investigate the effect of hypoxia inducible factor-1α (HIF-1α) on the
proliferation, migration and vasculogenic mimicry (VM) in human esophageal squamous cell …

Aim To study the expression of HIF-1alpha in serum of primary hepatocellular carcinoma
(PHC) and effects on tumor invasion and metastasis. Methods The serum HIF-1alpha level …

Hypoxia inducible factor 1α (HIF-1α) is highly expressed and is implicated in the progression
of esophageal squamous cell carcinoma. To investigate the potential mechanism by which …

Objective To explore whether hypoxia could promote epithelial-mesenchymal transition
(EMT) in various differentiated colorectal cancer cells, and analyse the effect of hypoxia on …

Objective To investigate the expression of HPA and HIF-1alpha in human esophageal
squamous cell carcinoma and their relationship with cancer development, invasion and …

The expression levels of hypoxia-inducible factor 1alpha (HIF-1α) and HIF-2α in pancreatic
cancer (PC) and their association with clinicopathologic characteristics were investigated in …