Nanotechnology-based radiation therapy to cure cancer and the challenges in its clinical applications

M Arif, AF Nawaz, H Mueen, F Rashid, HA Hemeg… - Heliyon, 2023 - cell.com
Radiation therapy against cancer frequently fails to attain the desired outcomes because of
several restricting aspects. Radiation therapy is not a targeted antitumor treatment, and it …

Multifunctional high-Z nanoradiosensitizers for multimodal synergistic cancer therapy

J Chen, H Dong, L Bai, L Li, S Chen, X Tian… - Journal of Materials …, 2022 - pubs.rsc.org
Radiotherapy (RT) is one of the most common and effective clinical therapies for malignant
tumors. However, there are several limitations that undermine the clinical efficacy of cancer …

Potential of natural products as radioprotectors and radiosensitizers: Opportunities and challenges

J Yi, J Zhu, C Zhao, Q Kang, X Zhang, K Suo, N Cao… - Food & Function, 2021 - pubs.rsc.org
Natural products can be used as natural radiosensitizers and radioprotectors, showing
promising effects in cancer treatments in combination with radiotherapy, while reducing …

Antioxidant nanomedicine significantly enhances the survival benefit of radiation cancer therapy by mitigating oxidative stress‐induced side effects

A Kim, C Yonemoto, CP Feliciano, B Shashni… - Small, 2021 - Wiley Online Library
Oxidative stress‐induced off‐target effects limit the therapeutic window of radiation therapy.
Although many antioxidants have been evaluated as radioprotective agents, none of them …

Research progress on nano-sensitizers for enhancing the effects of radiotherapy

Y Zhang, X Han, Y Liu, S Wang, X Han, C Cheng - Materials Advances, 2022 - pubs.rsc.org
Radiotherapy (RT) is local control of tumors using radiation, including external irradiation
(EBRT) and internal irradiation (RIT). Cancer radiotherapy based on external beams is a …

The refined application and evolution of nanotechnology in enhancing radiosensitivity during radiotherapy: transitioning from gold nanoparticles to multifunctional …

A Zhang, L Gao - International Journal of Nanomedicine, 2023 - Taylor & Francis
Radiotherapy is a pivotal method for treating malignant tumors, and enhancing the
therapeutic gain ratio of radiotherapy through physical techniques is the direction of modern …

The promise of nanoparticles-based radiotherapy in cancer treatment

M Haque, MS Shakil, KM Mahmud - Cancers, 2023 - mdpi.com
Simple Summary Radiotherapy (RT) is used worldwide as a gold standard treatment
approach for cancer management. However, the RT treatment modality contains limitations …

Hafnium oxide nanoparticles coated ATR inhibitor to enhance the radiotherapy and potentiate antitumor immune response

R Liu, C Zhang, X Wu, C Wang, M Zhao, C Ji… - Chemical Engineering …, 2023 - Elsevier
Nanomaterials as radioenhancer have been widely studied, which exhibits huge
advantages in tumor radiotherapy. However, DNA damage repair in tumor cells leads to …

Augmenting the therapeutic window of radiotherapy: A perspective on molecularly targeted therapies and nanomaterials

M Reda, AF Bagley, HY Zaidan, W Yantasee - Radiotherapy and Oncology, 2020 - Elsevier
Radiation therapy is a cornerstone of modern cancer therapy alongside surgery,
chemotherapy, and immunotherapy, with over half of all cancer patients receiving radiation …

Chemical and biological basis for development of novel radioprotective drugs for cancer therapy

R Checker, RS Patwardhan, S Jayakumar… - Free Radical …, 2021 - Taylor & Francis
Ionizing radiation (IR) causes chemical changes in biological systems through direct
interaction with the macromolecules or by causing radiolysis of water. This property of IR is …