Engineering nanoparticles to reprogram radiotherapy and immunotherapy: recent advances and future challenges

J Jin, Q Zhao - Journal of nanobiotechnology, 2020 - Springer
Nanoparticles (NPs) have been increasingly studied for radiosensitization. The principle of
NPs radio-enhancement is to use high-atomic number NPs (eg gold, hafnium, bismuth and …

Synergistically enhancing the therapeutic effect of radiation therapy with radiation activatable and reactive oxygen species-releasing nanostructures

K Cheng, M Sano, CH Jenkins, G Zhang, D Vernekohl… - ACS …, 2018 - ACS Publications
Nanoparticle-based radio-sensitizers can amplify the effects of radiation therapy on tumor
tissue even at relatively low concentrations while reducing the potential side effects to …

Targeted delivery of nano-radiosensitizers for tumor radiotherapy

S Shi, H Zhong, Y Zhang, Q Mei - Coordination Chemistry Reviews, 2024 - Elsevier
Radiotherapy is a major tumor treatment approach in clinical, however, the use of high-dose
X-rays during therapy inevitably causes damage to nearby healthy tissues, greatly reducing …

Multifaceted roles of a bioengineered nanoreactor in repressing radiation-induced lung injury

T Liu, Q Yang, H Zheng, H Jia, Y He, X Zhang, J Zheng… - Biomaterials, 2021 - Elsevier
Radiation‐induced lung injury (RILI) is a potentially fatal and dose-limiting complication of
thoracic cancer radiotherapy. However, effective therapeutic agents for this condition are …

Gold–iron selenide nanocomposites for amplified tumor oxidative stress-augmented photo-radiotherapy

J Lu, Z Guo, W Xie, Y Chi, J Zhang, W Xu, X Guo… - Biomaterials …, 2021 - pubs.rsc.org
The radio-resistance of tumor tissues has been considered a great challenge for cancer
radiotherapy (RT). The development of nanoparticle (NP)-based radio-sensitizers can …

Biological effects of radiation on cancer cells

J Wang, H Wang, H Qian - Military medical research, 2018 - Springer
With the development of radiotherapeutic oncology, computer technology and medical
imaging technology, radiation therapy has made great progress. Research on the impact …

Promoting reactive oxygen species generation: a key strategy in nanosensitizer-mediated radiotherapy

S Jia, S Ge, X Fan, KW Leong, J Ruan - Nanomedicine, 2021 - Taylor & Francis
The radiotherapy enhancement effect of numerous nanosensitizers is based on the
excessive production of reactive oxygen species (ROS), and only a few systematic reviews …

[HTML][HTML] Main approaches to enhance radiosensitization in cancer cells by nanoparticles: A systematic review

BB Abdollahi, R Malekzadeh, FP Azar… - Advanced …, 2021 - ncbi.nlm.nih.gov
In recent years, high atomic number nanoparticles (NPs) have emerged as promising radio-
enhancer agents for cancer radiation therapy due to their unique properties. Multi …

[HTML][HTML] Nanoparticles for radiation therapy enhancement: the key parameters

P Retif, S Pinel, M Toussaint, C Frochot, R Chouikrat… - Theranostics, 2015 - ncbi.nlm.nih.gov
This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It
does not establish an exhaustive list of the works in this field but rather propose constructive …

Radiation protection with nanoparticles

CH Baker - JSM Nanotechnol Nanomed, 2014 - api.taylorfrancis.com
At the onset of radiation exposure, free radicals are formed through ionizing reactions that
are then capable of destroying normal tissues. While cells release a level of protective …