[PDF][PDF] An ancient fecundability-associated polymorphism switches a repressor into an enhancer of endometrial TAP2 expression

KM Mika, VJ Lynch - The American Journal of Human Genetics, 2016 - cell.com
Variation in female reproductive traits, such as fertility, fecundity, and fecundability, is
heritable in humans, but identifying and functionally characterizing genetic variants …

[HTML][HTML] Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated …

CK Burrows, G Kosova, C Herman, K Patterson… - PLoS …, 2016 - journals.plos.org
Fertility traits in humans are heritable, however, little is known about the genes that influence
reproductive outcomes or the genetic variants that contribute to differences in these traits …

[PDF][PDF] An ancient fecundability-associated polymorphism creates a GATA2 binding site in a distal enhancer of HLA-F

KM Mika, X Li, FJ DeMayo, VJ Lynch - The American Journal of Human …, 2018 - cell.com
Variation in female reproductive traits, such as fertility, fecundity, and fecundability, are
heritable in humans, but identifying and functionally characterizing genetic variants …

[PDF][PDF] Genome-wide association study identifies candidate genes for male fertility traits in humans

G Kosova, NM Scott, C Niederberger, GS Prins… - The American Journal of …, 2012 - cell.com
Despite the fact that hundreds of genes are known to affect fertility in animal models,
relatively little is known about genes that influence natural fertility in humans. To broadly …

Gamete-level immunogenetic incompatibility in humans–towards deeper understanding of fertilization and infertility?

A Jokiniemi, L Kuusipalo, J Ritari, S Koskela… - Heredity, 2020 - nature.com
Human leukocyte antigen (HLA) immune genes play an important role in partner selection,
but it has remained unclear if nonrandom pairing with respect to parental HLA genes could …

Genome-wide association studies on endometriosis and endometriosis-related infertility

G Galarneau, P Fontanillas, Celmatix Research Team… - BioRxiv, 2018 - biorxiv.org
Endometriosis affects∼ 10% of women of reproductive age. It is characterized by the growth
of endometrial-like tissue outside the uterus and is frequently associated with severe pain …

The evolution of menstruation: a new model for genetic assimilation: explaining molecular origins of maternal responses to fetal invasiveness

D Emera, R Romero, G Wagner - Bioessays, 2012 - Wiley Online Library
Why do humans menstruate while most mammals do not? Here, we present our answer to
this long‐debated question, arguing that (i) menstruation occurs as a mechanistic …

[HTML][HTML] Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study

KL Spencer, J Malinowski, CL Carty, N Franceschini… - PloS one, 2013 - journals.plos.org
Age at menarche (AM) and age at natural menopause (ANM) define the boundaries of the
reproductive lifespan in women. Their timing is associated with various diseases, including …

TAp63 as a guardian of female germ line integrity

W Xian, F McKeon - Nature Structural & Molecular Biology, 2018 - nature.com
TAp63 as a guardian of female germ line integrity | Nature Structural & Molecular Biology Skip to
main content Thank you for visiting nature.com. You are using a browser version with limited …

The pregnancy pickle: evolved immune compensation due to pregnancy underlies sex differences in human diseases

H Natri, AR Garcia, KH Buetow, BC Trumble… - Trends in Genetics, 2019 - cell.com
We hypothesize that, ancestrally, sex-specific immune modulation evolved to facilitate
survival of the pregnant person in the presence of an invasive placenta and an …