Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) activity significantly increases during
cerebral ischemia/reperfusion. PARP-1 is an NAD+-consumption enzyme. PARP-1 …

Cerebral ischemia induces excessive activation of poly (ADP-ribose) polymerase-1 (PARP-
1), leading to neuronal cell death and the development of post-ischemic dysfunction …

Poly (ADP-ribose) polymerase-2 (PARP-2) is a member of the PARP enzyme family, and,
similarly to PARP-1, catalyzes the formation of ADP-ribose polymers in response to DNA …

Poly (ADP-ribose) polymerase (PARP, EC 2.4. 2.30), an abundant nuclear protein activated
by DNA nicks, mediates cell death in vitro by nicotinamide adenine dinucleotide (NAD) …

The activation of poly (ADP-ribose) polymerase-1 (PARP-1) after exposure to nitric oxide or
oxygen-free radicals can lead to cell injury via severe, irreversible depletion of NAD. Genetic …

Excessive activation of poly (ADP‐ribose) polymerase‐1 (PARP‐1) is known to develop
neuronal apoptosis, necrosis and inflammation after ischaemic brain injury. Therefore …

Poly (ADP-ribose) polymerases (PARPs) are enzymes that are able to catalyze the transfer
of ADP-ribose units from NAD to substrate proteins and are particularly abundant in cell …

Abstract Poly (ADP-ribose) polymerase (PARP)-1 is a DNA nick sensor that transforms ADP-
ribose from βNAD+ in the form of polymer to over 40 nuclear proteins, particularly to …

In the present study, the effect of poly (ADP-ribose) polymerase (PARP) inhibition on rat
cortical energy state was investigated at 24 h after global cerebral ischemia induced by …

The biological roles of poly (ADP-ribose) polymers (PAR) and poly (ADP-ribosyl) ation of
proteins in the central nervous system are diverse. The homeostasis of PAR orchestrated by …