pH-responsive cancer-targeted selenium nanoparticles: a transformable drug carrier with enhanced theranostic effects

B Yu, X Li, W Zheng, Y Feng, YS Wong… - Journal of Materials …, 2014 - pubs.rsc.org
Selenium nanoparticles (SeNPs) have been widely used in various biomedical applications,
including cancer therapy, diagnosis and drug delivery. Herein, we fabricated a novel type of …

Facile synthesis of highly uniform selenium nanoparticles using glucose as the reductant and surface decorator to induce cancer cell apoptosis

T Nie, H Wu, KH Wong, T Chen - Journal of Materials Chemistry B, 2016 - pubs.rsc.org
Selenium nanoparticles (SeNPs) have attracted increasing attention due to their potential
application as an effective drug delivery system. However, the conventional synthetic …

Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles

Y Huang, L He, W Liu, C Fan, W Zheng, YS Wong… - Biomaterials, 2013 - Elsevier
Selenium nanoparticles (SeNPs) have garnered a great deal of attention as potential cancer
therapeutic payloads. However, the in vivo targeting drug delivery has been challenging …

Rational design and fabrication of a cancer-targeted chitosan nanocarrier to enhance selective cellular uptake and anticancer efficacy of selenocystine

B Yu, H Li, J Zhang, W Zheng, T Chen - Journal of Materials Chemistry …, 2015 - pubs.rsc.org
The rational design and fabrication of nanodelivery systems to encapsulate drugs has been
proven to be a promising and effective strategy for cancer therapy. Selenocystine (SeC), a …

Autophagy is an important action mode for functionalized selenium nanoparticles to exhibit anti-colorectal cancer activity

G Huang, Z Liu, L He, KH Luk, ST Cheung… - Biomaterials …, 2018 - pubs.rsc.org
Selenium nanoparticles (SeNPs) have attracted much interest as potential anticancer
nanodrugs. Our previous studies also demonstrated that SeNPs could be developed as …

[HTML][HTML] Enhanced siRNA delivery and selective apoptosis induction in H1299 cancer cells by layer-by-layer-assembled Se nanocomplexes: Toward more efficient …

M Sharifiaghdam, E Shaabani… - Frontiers in molecular …, 2021 - frontiersin.org
Nanotechnology has made an important contribution to oncology in recent years, especially
for drug delivery. While many different nano-delivery systems have been suggested for …

Targeted therapeutic-immunomodulatory nanoplatform based on noncrystalline selenium

Q Chen, T Liu, S Chen, Y Luo, M Ma… - … applied materials & …, 2019 - ACS Publications
Developing versatile nanomaterials has offered a myriad of opportunities to surmount
cancer. In particular, the combination of therapy and immunomodulatory effect to further …

pH-responsive selenium nanoparticles stabilized by folate-chitosan delivering doxorubicin for overcoming drug-resistant cancer cells

U Luesakul, S Puthong, N Neamati, N Muangsin - Carbohydrate polymers, 2018 - Elsevier
Herein, we first report pH-responsive SeNPs stabilized with modified folic acid-N-trimethyl
chitosan (TMC-FA) as nanocarriers for delivery of doxorubicin (DOX) to overcome drug …

Selenium nanoparticles as a carrier of 5-fluorouracil to achieve anticancer synergism

W Liu, X Li, YS Wong, W Zheng, Y Zhang, W Cao… - ACS …, 2012 - ACS Publications
A simple method for preparing 5-fluorouracil surface-functionalized selenium nanoparticles
(5FU-SeNPs) with enhanced anticancer activity has been demonstrated in the present study …

Positive surface charge enhances selective cellular uptake and anticancer efficacy of selenium nanoparticles

B Yu, Y Zhang, W Zheng, C Fan, T Chen - Inorganic chemistry, 2012 - ACS Publications
Surface charge plays a key role in cellular uptake and biological actions of nanomaterials.
Selenium nanoparticles (SeNPs) are novel Se species with potent anticancer activity and …