Pyruvate kinase M2 at a glance
W Yang, Z Lu - Journal of cell science, 2015 - journals.biologists.com
Reprogrammed metabolism is a key feature of cancer cells. The pyruvate kinase M2 (PKM2)
isoform, which is commonly upregulated in many human cancers, has been recently shown …
isoform, which is commonly upregulated in many human cancers, has been recently shown …
The multifaceted regulation and functions of PKM2 in tumor progression
Z Li, P Yang, Z Li - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2014 - Elsevier
Tumor cells undergo metabolic rewiring from oxidative phosphorylation towards aerobic
glycolysis to maintain the increased anabolic requirements for cell proliferation. It is widely …
glycolysis to maintain the increased anabolic requirements for cell proliferation. It is widely …
Cancer‐associated mutations in human pyruvate kinase M2 impair enzyme activity
Mammalian pyruvate kinase catalyzes the final step of glycolysis, and its M2 isoform (PKM2)
is widely expressed in proliferative tissues. Mutations in PKM2 are found in some human …
is widely expressed in proliferative tissues. Mutations in PKM2 are found in some human …
Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells
M Tamada, M Suematsu, H Saya - Clinical cancer research, 2012 - AACR
The M2 splice isoform of pyruvate kinase (PKM2), an enzyme that catalyzes the later step of
glycolysis, is a key regulator of aerobic glycolysis (known as the Warburg effect) in cancer …
glycolysis, is a key regulator of aerobic glycolysis (known as the Warburg effect) in cancer …
Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered
S Zheng, Q Liu, T Liu, X Lu - Journal of physiology and biochemistry, 2021 - Springer
PKM2, pyruvate kinase type M2, has been shown to play a key role in aerobic glycolysis and
to regulate the malignant behaviors of cancer cells. Recently, PKM2 has been revealed to …
to regulate the malignant behaviors of cancer cells. Recently, PKM2 has been revealed to …
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
Although aerobic glycolysis (the Warburg effect) is a hallmark of cancer, key questions,
including when, how, and why cancer cells become highly glycolytic, remain less clear. For …
including when, how, and why cancer cells become highly glycolytic, remain less clear. For …
Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye
MA Kanow, MM Giarmarco, CSR Jankowski… - elife, 2017 - elifesciences.org
Here we report multiple lines of evidence for a comprehensive model of energy metabolism
in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose …
in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose …
[HTML][HTML] Pyruvate kinase M2 and cancer: an updated assessment
Cancer cells are characterized by high glycolytic rates to support energy regeneration and
anabolic metabolism, along with the expression of pyruvate kinase isoenzyme M2 (PKM2) …
anabolic metabolism, along with the expression of pyruvate kinase isoenzyme M2 (PKM2) …
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
Most tumor cells take up more glucose than normal cells but metabolize glucose via
glycolysis even in the presence of normal levels of oxygen, a phenomenon known as the …
glycolysis even in the presence of normal levels of oxygen, a phenomenon known as the …