Unlike healthy adult tissues, cancers produce energy mainly by aerobic glycolysis instead of
oxidative phosphorylation. This adaptation, called the Warburg effect, may be a feature of all …

Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting
step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is …

The origins and role of the Warburg effect have remained uncertain for many years. Two
recent studies demonstrate that an embryonic-and cancer-cell-specific isoform of the …

The Warburg effect, characterized by increased glucose uptake and lactate production, is a
well-known universal across cancer cells and other proliferating cells. PKM2, a splice …

Defects in energy metabolism in either the retina or the immediately adjacent retinal pigment
epithelium (RPE) underlie retinal degeneration, but the metabolic dependence between …

Rewiring glucose metabolism, termed as Warburg effect or aerobic glycolysis, is a common
signature of cancer cells to meet their high energetic and biosynthetic demands of rapid …

The M2 isoform of pyruvate kinase (PKM2) is highly expressed in most cancer cells, and has
been studied extensively as a driver of oncogenic metabolism. In contrast, the role of PKM2 …

Aryl-hydrocarbon receptor interacting protein-like 1 (AIPL1) is essential to stabilize cGMP
phosphodiesterase 6 (PDE6) in rod photoreceptors. Mutation of AIPL1 leads to loss of …

Pyruvate kinase (PK) catalyzes the last irreversible reaction of glycolysis pathway,
generating pyruvate and ATP, from Phosphoenol Pyruvate (PEP) and ADP precursors. In …

Cancer cells have distinctive demands for intermediates from glucose metabolism for
biosynthesis and energy in different cell cycle phases. However, how cell cycle regulators …