Pyruvate Kinase M2, a key enzyme in glycolysis, has garnered significant attention in cancer
research due to its pivotal role in the metabolic reprogramming of cancer cells. Originally …

Cancer cells exhibit several unique metabolic phenotypes that are critical for cell growth and
proliferation. Specifically, they overexpress the M2 isoform of the tightly regulated enzyme …

Cancer cell metabolism is exemplified by high glucose consumption and lactate production.
Pyruvate kinase (PK), which catalyzes the final step of glycolysis, has emerged as a …

The glycolytic key regulator pyruvate kinase M2 (M2-PK or PKM2) can switch between a
highly active tetrameric and an inactive dimeric form. The transition between the two …

Growth factors stimulate cells to take up excess nutrients and to use them for anabolic
processes. The biochemical mechanism by which this is accomplished is not fully …

Control of protein synthesis in insulin-responsive tissues has been well characterized, but
relatively little is known about how this process is regulated in nervous tissues. The retina …

Proliferating cells and tumor cells in particular express the pyruvate kinase isoenzyme type
M2 (M2-PK). Within the tumor metabolome M2-PK regulates the proportions of glucose …

Preferential expression of the low-activity (dimeric) M2 isoform of pyruvate kinase (PK) over
its constitutively active splice variant M1 isoform is considered critical for aerobic glycolysis …

purpose. To determine the metabolic conditions that provide maintenance of viability for
cultured rat RPE cells and to determine whether monocarboxylates such as lactate or …

The retina, like many cancers, produces energy from glycolysis even in the presence of
oxygen. This phenomenon is known as aerobic glycolysis and eponymously as the W …