Many tumour cells have elevated rates of glucose uptake but reduced rates of oxidative
phosphorylation. This persistence of high lactate production by tumours in the presence of …

Photoreceptors, the primary site of phototransduction in the retina, require energy and
metabolites to constantly renew their outer segments. They preferentially consume most …

The glycolytic enzyme pyruvate kinase (PK) is required for cancer development, and has
been implicated in the metabolic transition from oxidative to fermentative metabolism, the …

Pyruvate kinase catalyzes the rate-limiting final step of glycolysis, generating adenosine
triphosphate (ATP) and pyruvate. The M2 tumor-specific isoform of pyruvate kinase (PKM2) …

Pyruvate kinase isoform M2 (PKM2) activity is subject to complex allosteric regulation.
Recently, serine and SAICAR (succinylaminoimidazolecarboxamide ribose-5′-phosphate) …

We have previously demonstrated that enhanced aerobic glycolysis and/or autophagy in the
tumor stroma supports epithelial cancer cell growth and aggressive behavior, via the …

Normal proliferating cells and tumour cells in particular express the pyruvate kinase
isoenzyme type M2 (M2-PK, PKM2). The quaternary structure of M2-PK determines whether …

The number of human protein kinases is greater than 500, and they can be classified as
tyrosine kinases, serine or threonine kinases, and protein kinases with dual specificity for …

Cancer cells engage in a metabolic program to enhance biosynthesis and support cell
proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered …

It has been recognized that the rate-limiting function of pyruvate kinase M2 (PKM2) in
glycolysis plays an important role in distributing glycolytic intermediates for anabolic and …