The renin-angiotensin system plays an important role in the control of blood pressure (BP)
and renal function. To illuminate the importance of renin in the context of a disease …

The renin-angiotensin system plays a major role in the regulation of blood pressure and
electrolyte homeostasis in mammals. In this study, we subjected transgenic mice containing …

Hypertension is one of the most important risk factors and a leading cause of death from
cardiovascular and cerebrovascular diseases. Based on numerous previous studies …

Renin plays a central role in controlling blood pressure as it catalyzes the first step in the
production of angiotensin II. The aim of this study was to isolate fragments of the human …

The renin-angiotensin system is normally subject to servo control mechanisms that suppress
plasma renin levels in response to increased blood pressure and increase plasma renin …

Renin, the key regulated enzyme of the renin-angiotensin system regulates blood pressure,
fluid-electrolyte homeostasis, and renal morphogenesis. Whole body deletion of the renin …

The renin–angiotensin system (RAS) in the brain is a critical determinant of blood pressure,
but the mechanisms regulating RAS activity in the brain remain unclear. Expression of brain …

Renin, a major regulatory component of the renin-angiotensin system, plays a pivotal role in
regulating blood pressure and electrolyte homeostasis and is predominantly expressed in …

We showed recently that deletion of a strong enhancer located 2.7 kb upstream of the renin
gene in mice produces a strain with mild hypotension and salt-sensitivity. Here we set out to …

Hypertension is a polygenic and multi‐factorial disorder that is extremely prevalent in
western societies, and thus has received a great deal of attention by the research …