Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian mRNAs
MicroRNAs (miRNAs) interact with target sites located in the 3′ untranslated regions (3′
UTRs) of mRNAs to downregulate their expression when the appropriate miRNA is bound to …
UTRs) of mRNAs to downregulate their expression when the appropriate miRNA is bound to …
MicroRNA-repressed mRNAs contain 40S but not 60S components
B Wang, A Yanez, CD Novina - Proceedings of the National …, 2008 - National Acad Sciences
MicroRNAs (miRNAs) are small noncoding RNAs that may target more than one-third of
human genes, yet the mechanisms used by miRNAs to repress translation of target mRNAs …
human genes, yet the mechanisms used by miRNAs to repress translation of target mRNAs …
Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR
JR Lytle, TA Yario, JA Steitz - Proceedings of the National …, 2007 - National Acad Sciences
In animals, microRNAs (miRNAs) bind to the 3′ UTRs of their target mRNAs and interfere
with translation, although the exact mechanism of inhibition of protein synthesis remains …
with translation, although the exact mechanism of inhibition of protein synthesis remains …
The widespread impact of mammalian MicroRNAs on mRNA repression and evolution
Thousands of mammalian messenger RNAs are under selective pressure to maintain 7-
nucleotide sites matching microRNAs (miRNAs). We found that these conserved targets are …
nucleotide sites matching microRNAs (miRNAs). We found that these conserved targets are …
How do microRNAs regulate gene expression?
IG Cannell, YW Kong, M Bushell - Biochemical Society …, 2008 - portlandpress.com
miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-
transcriptionally. They generally bind to the 3′-UTR (untranslated region) of their target …
transcriptionally. They generally bind to the 3′-UTR (untranslated region) of their target …
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
MicroRNAs (miRNAs) are endogenously encoded small noncoding RNAs, derived by
processing of short RNA hairpins, that can inhibit the translation of mRNAs bearing partially …
processing of short RNA hairpins, that can inhibit the translation of mRNAs bearing partially …
A novel class of microRNA-recognition elements that function only within open reading frames
MicroRNAs (miRNAs) are well known to target 3′ untranslated regions (3′ UTRs) in
mRNAs, thereby silencing gene expression at the post-transcriptional level. Multiple reports …
mRNAs, thereby silencing gene expression at the post-transcriptional level. Multiple reports …
A biochemical approach to identifying microRNA targets
Identifying the downstream targets of microRNAs (miRNAs) is essential to understanding
cellular regulatory networks. We devised a direct biochemical method for miRNA target …
cellular regulatory networks. We devised a direct biochemical method for miRNA target …
MicroRNA binding sites in the coding region of mRNAs: extending the repertoire of post‐transcriptional gene regulation
It is well established that microRNAs (miRNAs) induce mRNA degradation by binding to 3′
untranslated regions (UTRs). The functionality of sites in the coding domain sequence …
untranslated regions (UTRs). The functionality of sites in the coding domain sequence …
[HTML][HTML] Short RNAs repress translation after initiation in mammalian cells
CP Petersen, ME Bordeleau, J Pelletier, PA Sharp - Molecular cell, 2006 - cell.com
MicroRNAs (miRNAs) are predicted to regulate 30% of mammalian protein-encoding genes
by interactions with their 3′ untranslated regions (UTRs). We use partially complementary …
by interactions with their 3′ untranslated regions (UTRs). We use partially complementary …
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