Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian mRNAs

S Gu, L Jin, F Zhang, P Sarnow, MA Kay - Nature structural & molecular …, 2009 - nature.com
MicroRNAs (miRNAs) interact with target sites located in the 3′ untranslated regions (3′
UTRs) of mRNAs to downregulate their expression when the appropriate miRNA is bound to …

MicroRNA-repressed mRNAs contain 40S but not 60S components

B Wang, A Yanez, CD Novina - Proceedings of the National …, 2008 - National Acad Sciences
MicroRNAs (miRNAs) are small noncoding RNAs that may target more than one-third of
human genes, yet the mechanisms used by miRNAs to repress translation of target mRNAs …

Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR

JR Lytle, TA Yario, JA Steitz - Proceedings of the National …, 2007 - National Acad Sciences
In animals, microRNAs (miRNAs) bind to the 3′ UTRs of their target mRNAs and interfere
with translation, although the exact mechanism of inhibition of protein synthesis remains …

The widespread impact of mammalian MicroRNAs on mRNA repression and evolution

KKH Farh, A Grimson, C Jan, BP Lewis, WK Johnston… - Science, 2005 - science.org
Thousands of mammalian messenger RNAs are under selective pressure to maintain 7-
nucleotide sites matching microRNAs (miRNAs). We found that these conserved targets are …

How do microRNAs regulate gene expression?

IG Cannell, YW Kong, M Bushell - Biochemical Society …, 2008 - portlandpress.com
miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-
transcriptionally. They generally bind to the 3′-UTR (untranslated region) of their target …

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

Y Zeng, R Yi, BR Cullen - Proceedings of the National …, 2003 - National Acad Sciences
MicroRNAs (miRNAs) are endogenously encoded small noncoding RNAs, derived by
processing of short RNA hairpins, that can inhibit the translation of mRNAs bearing partially …

A novel class of microRNA-recognition elements that function only within open reading frames

K Zhang, X Zhang, Z Cai, J Zhou, R Cao… - Nature structural & …, 2018 - nature.com
MicroRNAs (miRNAs) are well known to target 3′ untranslated regions (3′ UTRs) in
mRNAs, thereby silencing gene expression at the post-transcriptional level. Multiple reports …

A biochemical approach to identifying microRNA targets

FV Karginov, C Conaco, Z Xuan… - Proceedings of the …, 2007 - National Acad Sciences
Identifying the downstream targets of microRNAs (miRNAs) is essential to understanding
cellular regulatory networks. We devised a direct biochemical method for miRNA target …

MicroRNA binding sites in the coding region of mRNAs: extending the repertoire of post‐transcriptional gene regulation

A Brümmer, J Hausser - Bioessays, 2014 - Wiley Online Library
It is well established that microRNAs (miRNAs) induce mRNA degradation by binding to 3′
untranslated regions (UTRs). The functionality of sites in the coding domain sequence …

[HTML][HTML] Short RNAs repress translation after initiation in mammalian cells

CP Petersen, ME Bordeleau, J Pelletier, PA Sharp - Molecular cell, 2006 - cell.com
MicroRNAs (miRNAs) are predicted to regulate 30% of mammalian protein-encoding genes
by interactions with their 3′ untranslated regions (UTRs). We use partially complementary …