Sodium–calcium exchange (NCX) is the major calcium (Ca) efflux mechanism of ventricular
cardiomyocytes. Consequently the exchanger plays a critical role in the regulation of cellular …

Cardiac Na/Ca exchange function in rabbit, mouse and man: what's the difference? - Abstract
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Cardiovascular disease is a leading cause of death worldwide, with ischemic heart disease
alone accounting for> 12% of all deaths, more than HIV/AIDS, tuberculosis, lung, and breast …

Background—Sarcolemmal Na/Ca exchange (NCX) regulates cardiac Ca and contractility.
NCX function during the cardiac cycle is determined by intracellular [Ca] and [Na]([Ca] i, and …

Increased Na+-Ca2+ exchange (NCX) activity in heart failure and hypertrophy may
compensate for depressed sarcoplasmic reticular Ca2+ uptake, provide inotropic support …

In the heart, intracellular Na+ concentration ([Na+] i) is a key modulator of Ca 2+ cycling,
contractility and cardiac myocyte metabolism. Several Na+ transporters are electrogenic …

The excitation–contraction coupling (EC-coupling) links membrane depolarization with
contraction in cardiomyocytes. Ca 2+ induced opening of ryanodine receptors (RyRs) leads …

Abstract Intracellular [Na+]([Na+] i) is regulated in cardiac myocytes by a balance of Na+
influx and efflux mechanisms. In the normal cell there is a large steady state electrochemical …

We are studying both Na: Ca exchange stoichiometry and cytosolic [Ca]([Ca] i)‐dependent
regulation of Na–Ca exchange (NCX) in intact rabbit ventricular myocytes. Analysis of NCX …

Abstract Cardiac sarcolemmal Na+–Ca2+ exchange is a central component of Ca2+
signaling essential for Ca2+ extrusion and contributing to a variable degree to the …