The human multidrug resistance gene (MDR1) encodes for P-glycoprotein (P-gp) which is a
transmembrane transporter protein that acts as an efflux pump for a number of lypophilic …

The human multidrug-resistant gene (MDR1) encodes for P-glycoprotein (P-gp), which is a
membrane-bound effluxtransporter conferring resistance to a number of natural cytotoxic …

Abstract P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as
an energy-dependent efflux pump that exports its substrates out of the cell. PGP expression …

MDR1 (P‐glycoprotein) is an important factor in the disposition of many drugs, and the
involved processes often exhibit considerable interindividual variability that may be …

P-glycoprotein (PGP) is a transmembrane efflux transporter with an important role in drug
therapy. The level of PGP expression leads to relevant consequences in terms of efficacy …

The human multidrug resistance gene (MDR1), spanning greater than 200 kb, encodes for
the ATP-dependent membrane efflux transporter, P-glycoprotein (Pgp). Significant progress …

Aims To investigate the frequency of the single nucleotide polymorphism C3435T in exon 26
of the MDR1 gene in Asians and to determine the functional significance of this SNP with the …

In vivo and in vitro studies have demonstrated that P-glycoprotein (P-gp) plays a very
significant role in the ADME processes (absorption, distribution, metabolism, excretion) and …

Resumen WIELANDT N, Ana María; VOLLRATH R, Valeska y CHIANALE B, José.
Polimorfismos del gen de resistencia a múltiples drogas (MDR1) en poblaciones chilenas …

Background There are significant differences in drug responses among different ethnic
groups. The multidrug transporter P-gp, encoded by the MDR1 gene, plays a key role in …