C3435T, have been investigated. 1-3 Originally identified in a German Caucasian
population by Hoffmeyer et al., C3435T was found to correlate with P-gp expression in the …

OBJECTIVES: To investigate the genetic variability of multiple drug resistant 1 (MDR1) gene
C3435T polymorphism in four Southern Chinese populations. METHODS: Using …

Two representative genetic variants of the MDR1 gene, 3435C> T and 2677G> T/A, show
wide interethnic differences in its genetic polymorphism. In this study, the authors evaluated …

P-Glycoprotein (PGP) encoded by the multi-drug-resistance 1 (MDR1) gene is a member of
theATP-binding cassette (ABC) transporter family, drug-transporting proteins involved in the …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

P-Glycoprotein (P-gp, encoded by MDR1 gene) plays an important role in determining
bioavailability and pharmacologic effects of many drugs. There is increasing evidence that P …

Human P-glycoprotein (P-gp) is encoded by the MDR1 gene, which is located on
chromosomal region 7q21 and consists of 28 exons. To date, over 50 single nucleotide …

The MDR1 multidrug transporter regulates the traffic of drugs, peptides and xenobiotics into
the body as well as sensitive tissues like the brain, germ cells and the developing fetus …

OBJECTIVES: P-glycoprotein (P-gp) is significant from the viewpoint of pharmacokinetics/
pharmacodynamics (PK/PD). MDR1 gene encodes P-gp and has a wide variety of SNPs. As …

The allele and genotype frequencies of MDR1 C3435T polymorphism were determined in
185 unrelated healthy Tamilians. The genomic DNA was extracted from peripheral …