Transporter proteins, in particular P-glycoprotein (Pgp), are important determinants in
absorption, tissue targeting, and elimination of drugs. In addition to physiological and …

The three functional single-nucleotide polymorphisms (SNPs) of the MDR1 gene, C1236T,
G2677T/A, and C3435T, exhibit an interpopulation difference. In this study, we analyzed the …

The human multidrug resistance (MDR1) gene product P-glycoprotein is highly expressed in
intestinal epithelial cells, where it constitutes a barrier against xenobiotics, bacterial toxins …

The multidrug resistance (MDR1) gene product P-glycoprotein is a membrane bound protein
that functions as an ATP-dependent efflux pump, transporting exogenous and endogenous …

The multidrug resistance gene 1 (MDR1) encodes a membrane-bound phosphoglycoprotein
(P-gp). It functions as a transmembrane efflux pump for various structurally unrelated …

Background: P-glycoprotein (P-gp) is a transmembrane pump encoded by MDR1 gene. It
contributes in protection of the cells against xenobiotic and toxic compounds. P-gp also …

The blood-and tissue-concentrations, and thus the activity, of many drugs are influenced by
factors that are subject to inter-individual variation. Variables that influence blood levels are …

Single nucleotide polymorphisms (SNPs) in the MDR1 gene that are responsible for drug
efflux can cause toxicity. Therefore, this study determined the SNPs of the Korean MDR1 …

BACKGROUND AND OBJECTIVES: Expression of the multidrug resistance P-glycoprotein,
a transmembrane drug transporter, is influenced by recently described polymorphisms of the …

Evaluation of: Kimchi-Sarfaty C, Oh JM, Kim IW et al.: A 'silent 'polymorphism in the MDR1
gene changes substrate specificity. Science 315, 525–528 (2007). Individuals carrying silent …