CYP3A4 and MDR1 alleles in a Portuguese population
Polymorphisms in cytochrome P450 CYP3A4 and multidrug resistance (MDR) 1 genes
coding for the important drugmetabolising CYP3A4 and the ATP-binding cassette (ABC) …
coding for the important drugmetabolising CYP3A4 and the ATP-binding cassette (ABC) …
Identification of polymorphisms on the MDR1 gene among Turkish population and their effects on multidrug resistance in acute leukemia patients
Multidrug‐resistance (MDR) phenotype is a serious limitation to the effective
chemotherapeutic treatment of many cancer types, including leukemia. One of the most …
chemotherapeutic treatment of many cancer types, including leukemia. One of the most …
Haplotype-oriented genetic analysis and functional assessment of promoter variants in the MDR1 (ABCB1) gene
H Takane, D Kobayashi, T Hirota, J Kigawa… - … of Pharmacology and …, 2004 - ASPET
Recently, a number of nucleotide variants have been described in the multidrug resistance 1
(MDR1/ABCB1) gene; however, most studies have focused on the coding region. In the …
(MDR1/ABCB1) gene; however, most studies have focused on the coding region. In the …
Genotype Variability and Haplotype Frequency of MDR1 (ABCB1) Gene Polymorphism in Morocco
Y Kassogue, H Dehbi, S Nassereddine… - DNA and cell …, 2013 - liebertpub.com
The multidrug resistance gene (MDR1) plays an important role in the transport of a wide
range of drugs and elimination of xenobiotics from the body. Identification of polymorphisms …
range of drugs and elimination of xenobiotics from the body. Identification of polymorphisms …
[HTML][HTML] Association between the C3435T single-nucleotide polymorphism of multidrug resistance 1 gene and risk of gastric cancer
J Oliveira, AV Felipe, PYJ Chang… - Molecular …, 2012 - spandidos-publications.com
Abstract The multidrug resistance 1 (MDR1) gene encodes P-glycoprotein, which confers
resistance to antineoplastic drugs, but also affects the kinetic disposition of certain drugs and …
resistance to antineoplastic drugs, but also affects the kinetic disposition of certain drugs and …
Genetic polymorphisms in MDR1 and CYP3A5 and MDR1 haplotype in mainland Chinese Han, Uygur and Kazakh ethnic groups
D Li, GL Zhang, YQ Lou, Q Li, X Wang… - Journal of clinical …, 2007 - Wiley Online Library
Background and objective: The drug transporter MDR1 and the drug metabolizing enzyme
CYP3A are the two major biological factors determining the pharmacokinetics of many …
CYP3A are the two major biological factors determining the pharmacokinetics of many …
[HTML][HTML] Polymorphisms in the ABC drug transporter gene MDR1
U Brinkmann, M Eichelbaum - The pharmacogenomics journal, 2001 - nature.com
In addition to genetically variable metabolic enzymes such as Cyp p450 proteins, blood and
tissue levels of many drugs are influenced by controlled transport across compartmental …
tissue levels of many drugs are influenced by controlled transport across compartmental …
MDR1 genotype-related pharmacokinetics: fact or fiction?
T Sakaeda - Drug metabolism and pharmacokinetics, 2005 - jstage.jst.go.jp
Multidrug resistant transporter MDR1WP-glycoprotein, the gene product of MDR1, is a
glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette …
glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette …
The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells
M Hitzl, S Drescher, H van der Kuip… - Pharmacogenetics …, 2001 - journals.lww.com
P-glycoprotein (PGP) is a membrane protein which determines drug disposition in humans
(eg digoxin). It is also expressed in various leukocyte lineages with highest expression in …
(eg digoxin). It is also expressed in various leukocyte lineages with highest expression in …
Genetically determined differences in P-glycoprotein function: implications for disease risk
MF Fromm - Toxicology, 2002 - Elsevier
The MDR1 gene product P-glycoprotein does not only contribute to drug resistance during
chemotherapy of tumors but it is also expressed in healthy tissues with excretory function …
chemotherapy of tumors but it is also expressed in healthy tissues with excretory function …