The multi-drug resistant transporter MDR1/P-glycoprotein, the gene product of MDR1, is a
glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette (ABC) …

Several investigations demonstrated that the polymorphisms of multidrug resistance gene
(MDR1) gene contribute to interindividual variability in bioavailability and tissue distribution …

Crohn disease (CD) and ulcerative colitis (UC) are overlapping chronic inflammatory bowel
diseases (IBDs). Suggestive evidence for linkage at chromosome 7q has been reported for …

Resistance to established drugs for cancer therapy is in many cases associated with
overexpression of the multidrug resistance gene 1 (MDR-1). Regulation of basal expression …

Abstract Multidrug resistance 1 (MDR1) gene encodes the ATP-dependent cellular efflux
pump P-glycoprotein (P-gp) which efflux of a variety of substances across the membrane. P …

Background and Objectives There have been considerable disagreements regarding the
influence of MDR1 (ABCB1) polymorphisms on the disposition of P‐glycoprotein (P‐gp) …

Abstract P-glycoprotein (PGP), the product of the MDR1 gene, is a transmembrane active
efflux pump for a variety of carcinogens and cytostatics. It has been suggested that MDR1 …

One of the limitations in the treatment of cancer patients with chemotherapy is the
development of multidrug resistance (MDR). A well-known mechanism responsible for drug …

Active transport processes are now recognized as important determinants of drug absorption
and elimination. The role of the MDR1 gene product P-glycoprotein for drug disposition in …

Abstract Back ground and Aims The MDR1 (multidrug resistance) gene, located on
chromosome 7, is in one of the inflammatory bowel disease susceptibility loci. It produces P …