The concept of polymer–drug conjugates was proposed more than 30 years ago, and an N-
(2-hydroxypropyl) methacrylamide (HPMA) copolymer conjugate of doxorubicin covalently …

In this paper we describe the synthesis, physico-chemical characteristics and results of tests
of biological activity of polymer drugs based on conjugates of anti-cancer drug doxorubicin …

Use of polymeric drug delivery systems is rapidly becoming an established approach for
improvement of cancer chemotherapy. Zoladex (R), a poly lactide-co-glycolide …

The aim of this study was the synthesis, physico‐chemical characterization and preliminary
evaluation of biological activity of novel polymer drugs based on conjugates of anti‐cancer …

Copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) are prototypic and well-
characterized polymeric drug carriers that are being broadly implemented in the delivery of …

The state-of-the art in water-soluble macromolecular therapeutics has been reviewed. First
the design principles for polymer-drug conjugates are discussed followed by two recent …

Synthesis and physico-chemical behavior of new polymer–drug conjugates intended for the
treatment of cancer were investigated. In the polymer conjugate with the expected dual …

In recent years, polymer drug carriers based on N-(2-hydroxypropyl) methacrylamide
(HPMA) copolymers with pH-triggered drug release have shown enhanced uptake in solid …

A new strategy for the synthesis of biodegradable high molecular weight N-(2-
hydroxypropyl) methacrylamide (HPMA)-based polymeric carriers has been designed. An …

The design of targetable water-soluble polymeric drug carriers based on N-(2-
hydroxypropyl) methacrylamide (HPMA) copolymers is described. Three types of conjugates …