[HTML][HTML] Covalent polymer-drug conjugates

C Elvira, A Gallardo, JS Roman, A Cifuentes - Molecules, 2005 - mdpi.com
In this work, polymer-drugs conjugates used as drug delivery systems (DDS) are revised
attending to their chemical conjugation. Namely, the classification of this type of DDS is …

Improving the efficacy of combined modality anticancer therapy using HPMA copolymer-based nanomedicine formulations

T Lammers - Advanced drug delivery reviews, 2010 - Elsevier
Copolymers based on N-(2-hydroxypropyl) methacrylamide (HPMA) are prototypic and well-
characterized polymeric drug carriers that have been broadly implemented in the delivery of …

Synthetic macromolecular drug carriers: biodistribution of poly [(N-2-hydroxypropyl) methacrylamide] copolymers and their accumulation in solid rat tumors

M Kissel, P Peschke, V Subr, K Ulbrich… - PDA Journal of …, 2001 - journal.pda.org
To optimize polymer design for tumor directed drug delivery, the fate and the total body
distribution of soluble synthetic macromolecules, derived from copolymers of [(N-2 …

Self-assembled polyethylenimine-graft-poly (ε-caprolactone) micelles as potential dual carriers of genes and anticancer drugs

LY Qiu, YH Bae - Biomaterials, 2007 - Elsevier
A series of amphiphilic cationic graft polymers (PEC) were synthesized by coupling poly (ε-
caprolactone) of differing molecular weights (MW) to low MW branched polyethylenimine via …

[引用][C] Polymeric drug delivery systems

GS Kwon - 2005 - CRC Press

Molecular design of functional polymers for gene therapy

JH Jeong, SW Kim, TG Park - Progress in Polymer Science, 2007 - Elsevier
In the post genomic era, massive genetic information of the human being accelerates the
identification of target genes for treating various diseases. A wide range of nucleic acid …

Semitelechelic HPMA copolymers functionalized with triphenylphosphonium as drug carriers for membrane transduction and mitochondrial localization

J Callahan, J Kopeček - Biomacromolecules, 2006 - ACS Publications
Semitelechelic HPMA (N-(2-hydroxypropyl) methacrylamide) copolymers possessing a
single terminal lipophilic triphenylphosphonium (TPP) cation and fluorescent labels were …

Structure− activity relationships of water-soluble cationic methacrylate/methacrylamide polymers for nonviral gene delivery

P van de Wetering, EE Moret… - Bioconjugate …, 1999 - ACS Publications
A number of water-soluble cationic carriers was evaluated as transfectant. Almost all studied
cationic methacrylate/methacrylamide polymers were able to condense the structure of …

Polymer-drug conjugates: recent progress on administration routes

X Pang, X Yang, G Zhai - Expert opinion on drug delivery, 2014 - Taylor & Francis
Introduction: Polymer-drug conjugates are an important part of polymer therapeutics.
Recently, they have been used as an appealing platform for drug delivery. As a delivery …

Co-delivery of drug and DNA from cationic dual-responsive micelles derived from poly (DMAEMA-co-PPGMA)

XJ Loh, SJ Ong, YT Tung, HT Choo - Materials Science and Engineering: C, 2013 - Elsevier
The synthesis and gene transfection efficiency of a series of amphiphilic copolymers with
poly (dimethylaminoethyl methacrylate)(PDMAEMA), and poly (propylene glycol …