It is known that signaling from the germline stem cell niche is required to maintain germline
stem cell identity in Drosophila. However, it is not clear whether the germline stem-cell …

Steroid hormones are known systemic regulators of multiple normal and cancerous tissues;
however, whether or how they impact the fate and function of adult stem cells is unclear. In …

Previously, it has been shown that in Drosophila steroid hormones are required for
progression of oogenesis during late stages of egg maturation. Here, we show that …

During Drosophila oogenesis, germline stem cells (GSCs) self-renew and differentiate to
give rise to a mature egg. Self-renewal and differentiation of GSCs are regulated by both …

Highly potent animal stem cells either self renew or launch complex differentiation programs,
using mechanisms that are only partly understood. Drosophila female germline stem cells …

Stem cell maintenance depends on local signals provided by specialized
microenvironments, or niches, in which they reside. The potential role of systemic factors in …

Stem cells must proliferate while maintaining 'stemness'; however, much remains to be
learned about how factors that control the division of stem cells influence their identity …

Stem cell niches provide localized signaling molecules to promote stem cell fate and to
suppress differentiation. The Drosophila melanogaster ovarian niche is established by …

The signaling environment, or niche, often governs the initial difference in behavior of an
adult stem cell and a derivative that initiates a path towards differentiation. The transition …

The tight control of fate transitions during stem cell differentiation is essential for proper
tissue development and maintenance. However, the challenges in studying sparsely …