SIRT2, the predominantly cytosolic sirtuin, plays important role in multiple biological
processes, including metabolism, stress response, and aging. However, the function of …

Oxidative stress is a leading driver of ovarian aging. Silent mating-type information
regulation 2 homolog-1 (Sirt1) plays an role in ovarian function. Resveratrol has numerous …

Sir2, a NAD-dependent deacetylase, modulates lifespan in yeasts, worms and flies. The
SIRT1, mammalian homologue of Sir2, regulates signaling for favoring survival in stress. But …

Silent information Regulators (SIRT1) gene stimulates antioxidants' expression, repairs cells
damaged by oxidative stress (OS), and prevents the cells' dysfunction. In particular, the role …

Abstract Aims Sirtuin 3 (SIRT3) is a mitochondria-specific protein required for the
deacetylation of metabolic enzymes and the action of oxidative phosphorylation by acting as …

Mitochondrial function and glucose metabolism play important roles in bidirectional
signaling between granulosa cells (GCs) and oocytes. However, the factors associated with …

Pre-maturation aging of immature oocytes may adversely affect the fate of an oocyte.
Oxidative stress is one of the most detrimental factors affecting oocyte developmental …

Post-ovulatory aging, a major problem faced by oocytes cultured in vitro, causes oxidative
damage and mitochondrial dysfunction in oocytes. The ginsenoside Rh2 is one of the main …

Oxidative stress is one of the main causes of aging. The process of physiological aging is
always accompanied by increased levels of endogenous oxidative stress. Exogenous …

Background The global delay in women's reproductive age has raised concerns about age-
related infertility. The decline in oocyte quality is a limiting factor of female fertility, yet there …