The cerebral cortex, with all its computational power, can only influence behavior via
corticofugal connections originating from layer 5 (L5) cells (Sherman and Guillery, 2013). To …

The rodent retrosplenial cortex (RSC) functions as an integrative hub for sensory and motor
signals, serving roles in both navigation and memory. While RSC is reciprocally connected …

Active amplification of organized synaptic inputs in dendrites can endow individual neurons
with the ability to perform complex computations. However, whether dendrites in behaving …

Reciprocal interactions between the prefrontal cortex (PFC) and thalamus play a critical role
in cognition, but the underlying circuits remain poorly understood. Here we use optogenetics …

Intelligent behavior demands not only multiple forms of spatial representation, but also
coordination among the brain regions mediating those representations. Retrosplenial cortex …

The superior colliculus (SC) receives diverse and robust cortical inputs to drive a range of
cognitive and sensorimotor behaviors. However, it remains unclear how descending cortical …

The rodent homolog of the primate pulvinar, the lateral posterior (LP) thalamus, is
extensively interconnected with multiple cortical areas. While these cortical interactions can …

As we navigate in space, external landmarks and internal information guide our movement.
Circuit and synaptic mechanisms that integrate these cues with head-direction (HD) signals …

The claustrum is a telencephalic gray matter nucleus that is richly interconnected with the
neocortex. This structure subserves top-down executive functions that require frontal cortical …

Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the
ability to select appropriate responses from a vast behavioral repertoire. Modulation by the …