Hand factors in cardiac development
RM George, AB Firulli - The Anatomical Record, 2019 - Wiley Online Library
Congenital heart defects account for 1% of infant mortality and 10% of in utero deaths. As
the vertebrate embryo develops, multiple tissue types develop in tandem to morphologically …
the vertebrate embryo develops, multiple tissue types develop in tandem to morphologically …
Hand factors as regulators of cardiac morphogenesis and implications for congenital heart defects
JW Vincentz, RM Barnes… - Birth Defects Research Part …, 2011 - Wiley Online Library
Almost 15 years of careful study have established the related basic Helix‐Loop‐Helix
(bHLH) transcription factors Hand1 and Hand2 as critical for heart development across …
(bHLH) transcription factors Hand1 and Hand2 as critical for heart development across …
HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure
BA Firulli, RM George, J Harkin, KP Toolan… - Cardiovascular …, 2020 - academic.oup.com
Aims To examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in
embryonic and adult myocardium. Methods and results Hand1 is expressed within the …
embryonic and adult myocardium. Methods and results Hand1 is expressed within the …
The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner
DG McFadden, AC Barbosa, JA Richardson… - 2005 - journals.biologists.com
The basic helix-loop-helix transcription factors Hand1 and Hand2 display dynamic and
spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at …
spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at …
HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy
BD Thattaliyath, CB Livi, ME Steinhelper… - Biochemical and …, 2002 - Elsevier
The HAND basic Helix-Loop-Helix (bHLH) transcription factors are essential for normal
cardiac and extraembryonic development. Although highly evolutionarily conserved genes …
cardiac and extraembryonic development. Although highly evolutionarily conserved genes …
Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development
RM Barnes, BA Firulli, NJ VanDusen… - Circulation …, 2011 - Am Heart Assoc
Rationale: The basic helix–loop–helix (bHLH) transcription factors Hand1 and Hand2 are
essential for embryonic development. Given their requirement for cardiogenesis, it is …
essential for embryonic development. Given their requirement for cardiogenesis, it is …
HAND proteins: molecular mediators of cardiac development and congenital heart disease
D Srivastava - Trends in cardiovascular medicine, 1999 - Elsevier
Congenital heart defects are the clinical manifestation of anomalies in embryonic cardiac
development. Such defects occur in distinct regions or chambers of the heart. A molecular …
development. Such defects occur in distinct regions or chambers of the heart. A molecular …
[HTML][HTML] MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters
S Morin, G Pozzulo, L Robitaille, J Cross… - Journal of Biological …, 2005 - ASBMB
HAND proteins are tissue-restricted members of the basic helix-loop-helix transcription
factor family that play critical roles in cell differentiation and organogenesis including …
factor family that play critical roles in cell differentiation and organogenesis including …
Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis
The transcription factor HAND2 plays essential roles during cardiogenesis. Hand2
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …
Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor gene
MP Villanueva, AR Aiyer, S Muller, MT Pletcher, X Liu… - Genomics, 2002 - Elsevier
The helix-loop-helix transcription factor HAND2 plays a vital role in the development of the
heart, limb, facies, and other neural crest-derived structures. We used differential display …
heart, limb, facies, and other neural crest-derived structures. We used differential display …