A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans

J Wang, Y Zhang, C Lu, L Lei, P Yu… - The Journal of …, 2010 - journals.aai.org
A whole genome scale proteome array consisting of 908 open reading frames encoded in
Chlamydia trachomatis genome and plasmid was used to profile anti-chlamydial Ab …

High-throughput proteomic screening identifies Chlamydia trachomatis antigens that are capable of eliciting T cell and antibody responses that provide protection …

MD Picard, KP Cohane, TM Gierahn, DE Higgins… - Vaccine, 2012 - Elsevier
A comprehensive proteomic screening technology was previously used to characterize T
cell responses to Chlamydia trachomatis infection. In this study, we demonstrated that T cells …

Antigenic Profiling of a Chlamydia trachomatis Gene-Expression Library

F Follmann, AW Olsen, KT Jensen… - The Journal of …, 2008 - academic.oup.com
The obligate intracellular bacterium Chlamydia trachomatis is the causative agent of
sexually transmitted chlamydia infections. A panel of 116 recombinant C. trachomatis …

Identification of immunodominant antigens of Chlamydia trachomatis using proteome microarrays

DM Molina, S Pal, MA Kayala, A Teng, PJ Kim, P Baldi… - Vaccine, 2010 - Elsevier
Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen in the
world. In order to control this infection there is an urgent need to formulate a vaccine …

Identification of Immunodominant Antigens by Probing a Whole Chlamydia trachomatis Open Reading Frame Proteome Microarray Using Sera from Immunized Mice

MI Cruz-Fisher, C Cheng, G Sun, S Pal… - Infection and …, 2011 - Am Soc Microbiol
Chlamydia trachomatis infections can lead to severe chronic complications, including
trachoma, ectopic pregnancy, and infertility. The only effective approach to disease control is …

Profiling of Human Antibody Responses to Chlamydia trachomatis Urogenital Tract Infection Using Microplates Arrayed with 156 Chlamydial Fusion Proteins

J Sharma, Y Zhong, F Dong, JM Piper… - Infection and …, 2006 - Am Soc Microbiol
The available chlamydial genome sequences have made it possible to comprehensively
analyze host responses to all chlamydial proteins, which is essential for further …

Identification and characterization of novel recombinant vaccine antigens for immunization against genital Chlamydia trachomatis

RN Coler, A Bhatia, JF Maisonneuve… - FEMS Immunology & …, 2009 - academic.oup.com
Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection
worldwide, with over 91 million cases estimated annually. An effective subunit vaccine …

Chlamydial genomics and vaccine antigen discovery

RS Stephens - The Journal of infectious diseases, 2000 - academic.oup.com
Vaccine development for Chlamydia species has progressed on several research fronts,
including knowledge of the components of the immune response required for immunity and …

Development of a Chlamydia trachomatis T cell Vaccine

KP Karunakaran, H Yu, LJ Foster, RC Brunham - Human vaccines, 2010 - Taylor & Francis
The immune correlates of protection for most of the currently used vaccines are based on
long-lived humoral immunity. Vaccines based on humoral immunity alone are unlikely to …

Chlamydia trachomatis: Protective Adaptive Responses and Prospects for a Vaccine

TB Poston, T Darville - Biology of Chlamydia, 2018 - Springer
Chlamydia trachomatis is the most common cause of sexually transmitted bacterial infection
globally. These infections translate to a significant public health burden, particularly …