A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans
J Wang, Y Zhang, C Lu, L Lei, P Yu… - The Journal of …, 2010 - journals.aai.org
A whole genome scale proteome array consisting of 908 open reading frames encoded in
Chlamydia trachomatis genome and plasmid was used to profile anti-chlamydial Ab …
Chlamydia trachomatis genome and plasmid was used to profile anti-chlamydial Ab …
High-throughput proteomic screening identifies Chlamydia trachomatis antigens that are capable of eliciting T cell and antibody responses that provide protection …
MD Picard, KP Cohane, TM Gierahn, DE Higgins… - Vaccine, 2012 - Elsevier
A comprehensive proteomic screening technology was previously used to characterize T
cell responses to Chlamydia trachomatis infection. In this study, we demonstrated that T cells …
cell responses to Chlamydia trachomatis infection. In this study, we demonstrated that T cells …
Antigenic Profiling of a Chlamydia trachomatis Gene-Expression Library
F Follmann, AW Olsen, KT Jensen… - The Journal of …, 2008 - academic.oup.com
The obligate intracellular bacterium Chlamydia trachomatis is the causative agent of
sexually transmitted chlamydia infections. A panel of 116 recombinant C. trachomatis …
sexually transmitted chlamydia infections. A panel of 116 recombinant C. trachomatis …
Identification of immunodominant antigens of Chlamydia trachomatis using proteome microarrays
Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen in the
world. In order to control this infection there is an urgent need to formulate a vaccine …
world. In order to control this infection there is an urgent need to formulate a vaccine …
Identification of Immunodominant Antigens by Probing a Whole Chlamydia trachomatis Open Reading Frame Proteome Microarray Using Sera from Immunized Mice
MI Cruz-Fisher, C Cheng, G Sun, S Pal… - Infection and …, 2011 - Am Soc Microbiol
Chlamydia trachomatis infections can lead to severe chronic complications, including
trachoma, ectopic pregnancy, and infertility. The only effective approach to disease control is …
trachoma, ectopic pregnancy, and infertility. The only effective approach to disease control is …
Profiling of Human Antibody Responses to Chlamydia trachomatis Urogenital Tract Infection Using Microplates Arrayed with 156 Chlamydial Fusion Proteins
J Sharma, Y Zhong, F Dong, JM Piper… - Infection and …, 2006 - Am Soc Microbiol
The available chlamydial genome sequences have made it possible to comprehensively
analyze host responses to all chlamydial proteins, which is essential for further …
analyze host responses to all chlamydial proteins, which is essential for further …
Identification and characterization of novel recombinant vaccine antigens for immunization against genital Chlamydia trachomatis
RN Coler, A Bhatia, JF Maisonneuve… - FEMS Immunology & …, 2009 - academic.oup.com
Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection
worldwide, with over 91 million cases estimated annually. An effective subunit vaccine …
worldwide, with over 91 million cases estimated annually. An effective subunit vaccine …
Chlamydial genomics and vaccine antigen discovery
RS Stephens - The Journal of infectious diseases, 2000 - academic.oup.com
Vaccine development for Chlamydia species has progressed on several research fronts,
including knowledge of the components of the immune response required for immunity and …
including knowledge of the components of the immune response required for immunity and …
Development of a Chlamydia trachomatis T cell Vaccine
KP Karunakaran, H Yu, LJ Foster, RC Brunham - Human vaccines, 2010 - Taylor & Francis
The immune correlates of protection for most of the currently used vaccines are based on
long-lived humoral immunity. Vaccines based on humoral immunity alone are unlikely to …
long-lived humoral immunity. Vaccines based on humoral immunity alone are unlikely to …
Chlamydia trachomatis: Protective Adaptive Responses and Prospects for a Vaccine
TB Poston, T Darville - Biology of Chlamydia, 2018 - Springer
Chlamydia trachomatis is the most common cause of sexually transmitted bacterial infection
globally. These infections translate to a significant public health burden, particularly …
globally. These infections translate to a significant public health burden, particularly …