Cannabidiol treatment results in a common gene expression response across aggressive cancer cells from various origins

PY Desprez, R Murase, C Limbad… - Cannabis and …, 2021 - liebertpub.com
Background: We previously reported that cannabidiol (CBD), a cannabinoid with a low
toxicity profile, downregulated the expression of the prometastatic gene inhibitor of DNA …

[HTML][HTML] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma

YY Go, SR Kim, DY Kim, SW Chae, JJ Song - Scientific reports, 2020 - nature.com
Cannabidiol (CBD) has anti-tumorigenic activity. However, the anti-cancer effect of CBD on
head and neck squamous cell carcinoma (HNSCC) remains unclear. The cytotoxicity of CBD …

[HTML][HTML] Mechanisms of cannabidiol (CBD) in cancer treatment: A review

CG Heider, SA Itenberg, J Rao, H Ma, X Wu - Biology, 2022 - mdpi.com
Simple Summary Emerging evidence suggests positive outcomes from the use of CBD as a
cancer treatment. CBD can relieve cancer pain and ease the side effects of chemotherapy; …

Antitumor mechanism of cannabidiol hidden behind cancer hallmarks

C Yan, Y Li, H Liu, D Chen, J Wu - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Cannabinoids have been utilized for recreational and therapeutic purposes for over 4,000
years. As the primary ingredient in exogenous cannabinoids, Cannabidiol (CBD) has drawn …

Cannabidiol exerts anti-proliferative activity via a cannabinoid receptor 2-dependent mechanism in human colorectal cancer cells

HS Lee, G Tamia, HJ Song, D Amarakoon… - International …, 2022 - Elsevier
Colorectal cancer is the third leading cause of cancer incidence and mortality in the United
States. Cannabidiol (CBD), the second most abundant phytocannabinoid in Cannabis …

[HTML][HTML] Role of cannabidiol for improvement of the quality of life in cancer patients: potential and challenges

R Green, R Khalil, SS Mohapatra… - International Journal of …, 2022 - mdpi.com
There is currently a growing interest in the use of cannabidiol (CBD) to alleviate the
symptoms caused by cancer, including pain, sleep disruption, and anxiety. CBD is often self …

Inhalant cannabidiol inhibits glioblastoma progression through regulation of tumor microenvironment

H Khodadadi, ÉL Salles, A Alptekin… - Cannabis and …, 2023 - liebertpub.com
Introduction: Glioblastoma (GBM) is the most common invasive brain tumor composed of
diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) …

[HTML][HTML] Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect

M Solinas, P Massi, V Cinquina, M Valenti… - PLoS …, 2013 - journals.plos.org
In the present study, we found that CBD inhibited U87-MG and T98G cell proliferation and
invasiveness in vitro and caused a decrease in the expression of a set of proteins …

[HTML][HTML] Cannabidiol (CBD) as a promising anti-cancer drug

ES Seltzer, AK Watters, D MacKenzie, LM Granat… - Cancers, 2020 - mdpi.com
Recently, cannabinoids, such as cannabidiol (CBD) and Δ 9-tetrahydrocannabinol (THC),
have been the subject of intensive research and heavy scrutiny. Cannabinoids encompass a …

[HTML][HTML] The heterogeneity and complexity of Cannabis extracts as antitumor agents

L Baram, E Peled, P Berman, B Yellin, E Besser… - Oncotarget, 2019 - ncbi.nlm.nih.gov
The Cannabis plant contains over 100 phytocannabinoids and hundreds of other
components. The biological effects and interplay of these Cannabis compounds are not fully …