Background: Beta-2 adrenergic receptors (β2ARs) but not beta-2 adrenergic receptors
(β1ARs) form a functional complex with L-type Ca2+ channels (LTCCs) on the …

Influx of Ca2+ through L-type Ca2+ channels (LTCCs) contributes to numerous cellular
processes in cardiomyocytes including excitation–contraction (EC) coupling, membrane …

The purpose of this study was to investigate whether caveolin-3 (Cav3) regulates
localization of β 2-adrenergic receptor (β 2 AR) and its cAMP signaling in healthy or failing …

L-type Ca channels (LTCC), which play a key role in cardiac excitation–contraction coupling,
are located predominantly at the transverse (t-) tubules in ventricular myocytes. Caveolae …

Caveolin (Cav)-1 has been involved in the pathogenesis of ischemic injuries. For instance,
modulations of Cav-1 expression have been reported in animal models of myocardial …

Aims L-type Ca2+ channels (LTCCs) in adult cardiomyocytes are localized to t-tubules
where they initiate excitation-contraction coupling. Our recent work has shown that a …

Rationale: The source of Ca2+ to activate pathological cardiac hypertrophy is not clearly
defined. Ca2+ influx through the L-type Ca2+ channels (LTCCs) determines “contractile” …

New Findings What is the central question of this study? What is the cellular basis of the
protection conferred on the heart by overexpression of caveolin‐3 (Cav‐3 OE) against many …

L-type Ca2+ channels play a critical role in regulating Ca2+-dependent signaling in cardiac
myocytes, including excitation-contraction coupling; however, the subcellular localization of …

Activation of CaMKII induces a myriad of biological processes and plays dominant roles in
cardiac hypertrophy. Caveolar microdomain contains many calcium/calmodulin-dependent …