Rationale: Sympathetic stimulation of the heart increases the force of contraction and rate of
ventricular relaxation by triggering protein kinase (PK) A-dependent phosphorylation of …

Abstract β1 integrins (β1) transduce mechanical signals in many cells, including cardiac
myocytes (CM). Given their close localization, as well as their role in mechanotransduction …

The actions of catecholamines on adrenergic receptors (ARs) induce sympathetic
responses, and sustained activation of the sympathetic nervous system results in disrupted …

A growing body of evidence suggests that muscle cell caveolae may function as specialized
membrane micro-domains in which the dystrophin-glycoprotein complex and cellular …

Caveolae and caveolin are key players in a number of disease processes. Current research
indicates that caveolins play a significant role in cardiovascular disease and dysfunction …

We have recently demonstrated that in human heart, β 2-adrenergic receptors (β 2-ARs) are
biochemically coupled not only to the classical adenylyl cyclase (AC) pathway but also to the …

Myocardial ischemia/reperfusion (I/R) injury is a major cause of morbidity and mortality
worldwide. Caveolae, caveolin-1 (Cav-1), and caveolin-3 (Cav-3) are essential for the …

Myocardial ischemia/reperfusion injury is a major cause of morbidity and mortality. The
molecular signaling pathways involved in cardiac protection from myocardial …

Recently, development of a caveolin-1-deficient (Cav-1 null) mouse model has allowed the
detailed analysis of caveolin-1's function in the context of a whole animal. Interestingly, we …

Objectives: We hypothesized that cardiac myocyte-specific overexpression of caveolin-3
(Cav-3), a muscle-specific caveolin, would alter natriuretic peptide signaling and attenuate …