Impact of genes and the environment on the pathogenesis and disease course of inflammatory bowel disease

M Zhao, J Burisch - Digestive diseases and sciences, 2019 - Springer
Crohn's disease and ulcerative colitis constitute two major subgroups of inflammatory bowel
diseases (IBD), a group of complex polygenic diseases characterized by chronic and …

[HTML][HTML] Inflammatory bowel disease: pathogenesis

YZ Zhang, YY Li - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is
characterized by chronic relapsing intestinal inflammation. It has been a worldwide health …

Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics

NT Ventham, NA Kennedy, ER Nimmo, J Satsangi - Gastroenterology, 2013 - Elsevier
In the past decade, there have been fundamental advances in our understanding of genetic
factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and …

Inflammatory bowel disease: review from the aspect of genetics

S Ishihara, MM Aziz, T Yuki, H Kazumori… - Journal of …, 2009 - Springer
Regardless of how inflammatory bowel disease (IBD) is defined, the term “genetic
susceptibility” is always included. Due to substantial progress in the characterization of …

The epidemiology of inflammatory bowel disease: East meets west

WY Mak, M Zhao, SC Ng… - Journal of gastroenterology …, 2020 - Wiley Online Library
The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade
to become a global disease. The increasing number of studies on the incidence and course …

Role of genes, the environment and their interactions in the etiology of inflammatory bowel diseases

FE Ahmed - Expert review of molecular diagnostics, 2006 - Taylor & Francis
Few of the studied genes demonstrate association with inflammatory bowel disease (IBD).
Three mutations in the nucleotide-binding oligomerization domain 2 gene have consistently …

The genetics of Crohn's disease and ulcerative colitis – status quo and beyond

D Ellinghaus, J Bethune, BS Petersen… - Scandinavian journal of …, 2015 - Taylor & Francis
The two major subtypes of inflammatory bowel disease (IBD), ulcerative colitis (UC, MIM#
191390) and Crohn's disease (CD, MIM# 266600), are chronic relapsing-remitting …

The genetic basis of inflammatory bowel disease

R Cooney, D Jewell - Digestive diseases, 2009 - karger.com
Twin studies and large-scale population studies have confirmed an increased sibling risk for
both Crohn's disease (CD) and ulcerative colitis (UC). Unlike single gene disorders, CD and …

[HTML][HTML] Genetic factors associated with the development of inflammatory bowel disease

JK Yamamoto-Furusho - World Journal of Gastroenterology: WJG, 2007 - ncbi.nlm.nih.gov
Crohn's disease (CD) and ulcerative colitis (UC) are complex polygenic disorders,
characterized by several genes together with environmental factors contributing to the …

Inflammatory bowel disease: genetics, epigenetics, and pathogenesis

I Loddo, C Romano - Frontiers in immunology, 2015 - frontiersin.org
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by
chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent …