Patients requiring chronic opioid therapy may not respond to or tolerate the first opioid
prescribed to them, necessitating rotation to another opioid. They may also require dose …

Introduction Although chronic opioid therapy is usually initiated using short-acting opioids,
many patients with chronic pain are subsequently converted to long-acting and extended …

Opioid rotation is a strategy applied during opioid therapy for pain that refers to a switch from
one opioid to another in an effort to improve clinical outcomes (benefits or harms). It begins …

Objective. An increasing number of deaths have been inferred to be associated with current
opioid rotation practices and evidence is mounting that the use of widely accepted protocols …

Background: Opioid therapy is the standard treatment for moderate-to-severe cancer pain
and is becoming a more frequent treatment for moderate-to-severe chronic noncancer pain …

Opioid rotation refers to a switch from one opioid to another in an effort to improve the
response to analgesic therapy or reduce adverse effects. It is a common method to address …

Cancer is a public health problem worldwide and a major cause of death or disability. Pain
is one of the most common and feared symptoms in patients with cancer with marked impact …

Objectives. A dramatic increase in unintentional deaths from opioids has occurred over the
past decade with strong inference that many of these deaths may be resulting from …

The management of chronic pain remains a challenge because of its complexity and
unpredictable response to pharmacological treatment. In addition, accurate pain …

Introduction Opioid stewardship has been widely used to promote rational use, monitoring
and discontinuation of opioid therapy; however, its definition and scope of practice remain …