The spectrum of inflammatory diseases is nowadays considered to include diverse diseases
of the central nervous system (CNS). Current evidence suggests that syndromes such as …

Increasing evidence suggests that inflammatory and immune components in brain are
important in Alzheimer's disease (AD) and anti-inflammatory and immunotherapeutic …

Alzheimer's disease is a type of dementia characterized by problems with short-term
memory, cognition, and difficulties with activities of daily living. It is a progressive …

The complement system is a critical element of the innate immune system recognizing and
killing, or targeting for destruction, otherwise pathogenic organisms. In addition to triggering …

The emergence of complement as an important player in normal brain development and
pathological remodelling has come as a major surprise to most scientists working in …

The brain is considered to be an immune privileged site, because the blood–brain barrier
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …

There is increasing evidence from genetic, immunohistochemical, proteomic and
epidemiological studies as well as in model systems that complement activation has an …

The complement system provides an innate defence mechanism against pathogenic
microorganisms. Although viewed for many years as an immune-privileged organ, the …

As an essential component of our innate immune system, the complement system is
responsible for our defense against pathogens. The complement cascade has complex …

The complement inflammatory cascade is an essential component of the phylogenetically
ancient innate immune response and is crucial to our natural ability to ward off infection …