Elastin has long been thought to play a pivotal role in alveolar septal development by
providing the structural framework around which new alveoli develop in the immature lung …

Elastic fibers play a vital role in secondary septal development during the process of lung
alveolization. The authors present a quantitative study by image analysis and by high …

Prolonged hyperoxic exposure is associated with impaired alveolarization of the lung in both
the rat and the human neonate. Elastin is currently thought to play a pivotal role in the …

The structural development of the fetal guinea pig lung is described and quantified
morphometrically in this report. At 35 days gestation the lung is in the pseudoglandular …

Background The increase in the distal air spaces which takes place with age is the only
sufficiently documented datum for differentiation between the senile and the adult lung …

The length of elastic fibers and the distribution of fiber diameters was determined by
morphometry in the parenchyma of human lungs. Studies were done on 33 lungs from male …

We have quantified the fibrous collagen (predominantly type I) and elastin in four locations
of perceived mechanical importance: one quasi-planar feature, the alveolar septum or wall …

Lung alveolarization requires precise coordination of cell growth with extracellular matrix
(ECM) synthesis and deposition. The role of extracellular matrices in alveogenesis is not …

The rate of soluble elastin synthesis was estimated in lung explants from rats of differing
ages to better define periods in lung development important to the deposition of lung elastin …

Elastin is a major component of the mammalian lung, predominantly found in the alveoli.
Destruction of alveolar elastic fibers is implicated in the pathogenic mechanism of …