Lymph node biopsy is employed in many cancer surgeries to identify metastatic disease and
to determine cancer stage, yet morbidity and diagnostic delays associated with lymph node …

Lymph node metastasis is an indicator of the invasiveness and aggressiveness of cancer. It
is a vital prognostic factor in clinical staging of the disease and therapeutic decision-making …

Precision medicine is critically dependent on better methods for diagnosing and staging
disease and predicting drug response. Histopathology using hematoxylin and eosin (H&E) …

Lymph node metastasis is a strong predictor of poor outcome in cancer patients. Animal
studies of lymph node metastasis are constrained by difficulties in the establishment of …

Stochastic and proliferative events initiated from a single cell can disrupt homeostatic
balance and lead to fatal disease processes such as cancer metastasis. To overcome …

Imaging plays a central role in the diagnosis of cancer and the evaluation of therapeutic
efficacy in patients with cancer. Because macroscopic imaging is noninvasive and …

The development of methods to accurately quantify cell-surface receptors in living tissues
would have a seminal impact in oncology. For example, accurate measures of receptor …

Advances in multiplexed in situ imaging are revealing important insights in spatial biology.
However, cell type identification remains a major challenge in imaging analysis, with most …

Metastatic spread to regional lymph nodes is one of the earliest events of tumor cell
dissemination and presents a most significant prognostic factor for predicting survival of …

Purpose Correctly identifying nodal status is recognized as a critical prognostic factor in
many cancer types and is essential to guide adjuvant treatment. Currently, surgical removal …