The genomics of schizophrenia: update and implications

P Giusti-Rodríguez, PF Sullivan - The Journal of clinical …, 2013 - Am Soc Clin Investig
Schizophrenia is strongly familial yet rarely (if ever) exhibits classical Mendelian inheritance
patterns. The advent of large-scale genotyping and sequencing projects has yielded large …

New discoveries in schizophrenia genetics reveal neurobiological pathways: a review of recent findings

AV Kotlar, KB Mercer, ME Zwick, JG Mulle - European journal of medical …, 2015 - Elsevier
Schizophrenia research has undergone a recent transformation. By leveraging large sample
sizes, genome-wide association studies of common genetic variants have approximately …

The genetic architecture of schizophrenia: new mutations and emerging paradigms

L Rodriguez-Murillo, JA Gogos… - Annual review of …, 2012 - annualreviews.org
Although a genetic component of schizophrenia has been acknowledged for a long time, the
underlying architecture of the genetic risk remains a contentious issue. Early linkage and …

Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era

G Costain, AS Bassett - The application of clinical genetics, 2012 - Taylor & Francis
Schizophrenia is a complex neuropsychiatric disease with documented clinical and genetic
heterogeneity, and evidence for neurodevelopmental origins. Driven by new genetic …

Schizophrenia genetics: emerging themes for a complex disorder

DH Kavanagh, KE Tansey, MC O'Donovan… - Molecular …, 2015 - nature.com
After two decades of frustration, genetic studies of schizophrenia have entered an era of
spectacular success. Advances in genotyping technologies and high throughput …

Genetics of schizophrenia

I Escudero, M Johnstone - Current psychiatry reports, 2014 - Springer
The genetic basis of schizophrenia has been a hotly debated research topic for decades, yet
recent studies, especially in the past year, have confirmed genetics as the major cause of …

Schizophrenia genomics: genetic complexity and functional insights

PF Sullivan, S Yao, J Hjerling-Leffler - Nature Reviews Neuroscience, 2024 - nature.com
Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …

Genetic architecture of schizophrenia: a review of major advancements

SE Legge, ML Santoro, S Periyasamy… - Psychological …, 2021 - cambridge.org
Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and
technological advancements have led to a substantial increase in knowledge of the genetic …

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …

Genetics of schizophrenia: ready to translate?

C Foley, A Corvin, S Nakagome - Current psychiatry reports, 2017 - Springer
Abstract Purpose of Review This is an era where we have significantly advanced the
understanding of the genetic architecture of schizophrenia. In this review, we consider how …