Severe acute respiratory syndrome coronavirus-2 accessory proteins ORF3a and ORF7a modulate autophagic flux and Ca2+ homeostasis in yeast

JL Garrido-Huarte, J Fita-Torró, R Viana… - Frontiers in …, 2023 - frontiersin.org
Virus infection involves the manipulation of key host cell functions by specialized virulence
proteins. The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) small …

SARS-CoV-2 accessory proteins ORF3a and ORF7a modulate autophagic flux and Ca2+ homeostasis in yeast

J Luis Garrido-Huarte, J Fita-Torró, R Viana… - BioRxiv, 2022 - biorxiv.org
Virus infection involves the manipulation of key host cell functions by specialized virulence
proteins. The SARS-CoV-2 small accessory proteins ORF3a and ORF7a have been …

SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux

A Mozzi, M Oldani, ME Forcella, C Vantaggiato… - Iscience, 2023 - cell.com
Coronaviruses encode a variable number of accessory proteins that are involved in host-
virus interaction, suppression of immune responses, or immune evasion. SARS-CoV-2 …

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

AN Miller, PR Houlihan, E Matamala… - Elife, 2023 - elifesciences.org
The severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) and SARS-
CoV-1 accessory protein Orf3a colocalizes with markers of the plasma membrane, endocytic …

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

Y Zhang, H Sun, R Pei, B Mao, Z Zhao, H Li, Y Lin, K Lu - Cell discovery, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing
coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to …

Endoplasmic reticulum-associated SARS-CoV-2 ORF3a elicits heightened cytopathic effects despite robust ER-associated degradation

J Zhang, R Cruz-Cosme, C Zhang, D Liu, Q Tang… - Mbio, 2024 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF3a protein plays a vital
role in viral pathogenesis and coronavirus disease 2019 (COVID-19). Like the spike protein …

SARS-CoV-2 accessory protein ORF8 is secreted extracellularly as a glycoprotein homodimer

K Matsuoka, N Imahashi, M Ohno, H Ode… - Journal of Biological …, 2022 - ASBMB
ORF8 is an accessory protein encoded by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2). Consensus regarding the biological functions of ORF8 is lacking, largely …

Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

[HTML][HTML] SARS-CoV-2 ORF7a protein blocks virusclearance by regulating autophagy: SARS-CoV-2 ORF7a blocks virus clearance by regulating autophagy

H Liu, Q Li, L Li - Acta Biochimica et Biophysica Sinica, 2023 - ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has become a serious public health threat …

SARS-CoV-2 ORF8 accessory protein is a virulence factor

M Bello-Perez, J Hurtado-Tamayo, AZ Mykytyn… - Mbio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes six accessory
proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in …