Dengue virus (DV) infections are a serious public health problem and there is currently no
vaccine or drug treatment. NS2B/NS3 protease, an essential enzyme for viral replication, is …

Dengue is a serious disease which has become a global health burden in the last decade.
Currently, there are no approved vaccines or antiviral therapies to combat the disease. The …

Dengue fever is a tropical endemic disease that is transmitted by the female Aedes aegypti
mosquitoes around the world. In dengue patients, the severe vascular leak, bleeding and …

Dengue fever is a growing global health problem, with millions of virus illnesses occurring
each year. Unfortunately, there is no approved treatment available. DENV NS5 RdRp …

Dengue is one of the deadliest mosquito‐borne viral diseases. Since its inception, a lot of
research has happened in various directions, still no effective antiviral drug is available to …

The allosteric pocket of the Dengue virus (DENV2) NS2B/NS3 protease, which is proximal to
its catalytic triad, represents a promising drug target (Othman et al., 2008). We have …

Dengue infection has turned into a serious health concern globally due to its high morbidity
rate and a high possibility of increase in its mortality rate on the account of unavailability of …

Aedes aegypti is the primary vector for the transmission of the dengue virus (DENV), which
causes dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome …

Dengue virus has emerged as infectious mosquito borne disease involved in lowering
platelets and white blood cells (WBC) count particularly. The genome structure is based on …

By virtual screening, compound 1 was found to be active against NS2B-NS3 protease
(IC50= 13.12±1.03 μM). Fourteen derivatives (22) of compound 1 were synthesized, leading …