[HTML][HTML] Increased inflammation and unchanged density of synaptic vesicle glycoprotein 2A (SV2A) in the postmortem frontal cortex of Alzheimer's disease patients
A Metaxas, C Thygesen, SRR Briting… - Frontiers in cellular …, 2019 - frontiersin.org
Sections from the middle frontal gyrus (Brodmann area 46) of autopsy-confirmed Alzheimer's
disease (AD) patients and non-demented subjects were examined for the prevalence of …
disease (AD) patients and non-demented subjects were examined for the prevalence of …
[HTML][HTML] Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns
Background The synaptic vesicle glycoprotein 2 (SV2) family is essential to the synaptic
machinery involved in neurotransmission and vesicle recycling. The isoforms SV2A, SV2B …
machinery involved in neurotransmission and vesicle recycling. The isoforms SV2A, SV2B …
Lack of synaptic vesicle protein SV2B protects against amyloid-β25–35-induced oxidative stress, cholinergic deficit and cognitive impairment in mice
E Detrait, T Maurice, E Hanon, K Leclercq… - Behavioural brain …, 2014 - Elsevier
SV2B is a synaptic protein widely distributed throughout the brain, which is part of the
complex vesicle protein machinery involved in the regulation of synaptic vesicle endocytosis …
complex vesicle protein machinery involved in the regulation of synaptic vesicle endocytosis …
Synaptic vesicle protein 2B negatively regulates the Amyloidogenic processing of AβPP as a novel interaction partner of BACE1
M Miyamoto, A Kuzuya, Y Noda, S Ueda… - Journal of …, 2020 - content.iospress.com
Background: Given that amyloid-β (Aβ) peptide is produced and released at synapses,
synaptic Aβ is one of the promising therapeutic targets to prevent synaptic dysfunction in …
synaptic Aβ is one of the promising therapeutic targets to prevent synaptic dysfunction in …
Identification of a New Synaptic Vesicle Protein 2B mRNA Transcript Which Is Up-Regulated in Neurons by Amyloid β Peptide Fragment (1–42)
K Heese, Y Nagai, T Sawada - Biochemical and biophysical research …, 2001 - Elsevier
The treatment of Alzheimer's disease (AD) remains a major challenge because of the
incomplete understanding of the triggering events that lead to the selective …
incomplete understanding of the triggering events that lead to the selective …
[HTML][HTML] Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility
D Sevlever, F Zou, L Ma, S Carrasquillo… - Molecular …, 2015 - Springer
Background Alzheimer's disease is a neurodegenerative disorder in which extracellular
deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory …
deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory …
Tracing synaptic loss in Alzheimer's brain with SV2A PET‐tracer UCB‐J
A Kumar, M Scarpa, A Nordberg - Alzheimer's & Dementia, 2024 - Wiley Online Library
INTRODUCTION Synaptic loss is an early prominent feature of Alzheimer's disease (AD).
The recently developed novel synaptic vesicle 2A protein (SV2A) PET‐tracer UCB‐J has …
The recently developed novel synaptic vesicle 2A protein (SV2A) PET‐tracer UCB‐J has …
Expression pattern of synaptic vesicle protein 2 (SV 2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis
J Crèvecœur, RM Kaminski, B Rogister… - Neuropathology and …, 2014 - Wiley Online Library
Aims Synaptic vesicle proteins 2 (SV 2) are neuronal vesicles membrane glycoproteins that
appear as important targets in the treatment of partial and generalized epilepsies. Therefore …
appear as important targets in the treatment of partial and generalized epilepsies. Therefore …
[HTML][HTML] Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer's disease continuum
J Goossens, A Cervantes González, N Dewit… - Alzheimer's Research & …, 2023 - Springer
Background Synapse loss is an early event that precedes neuronal death and symptom
onset and is considered the best neuropathological correlate of cognitive decline in …
onset and is considered the best neuropathological correlate of cognitive decline in …
[HTML][HTML] Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)
BA Pazarlar, SS Aripaka, V Petukhov, L Pinborg… - Molecular brain, 2022 - Springer
Abstract Synaptic vesicle glycoprotein-2 (SV2) is a family of proteins consisting of SV2A,
SV2B, and SV2C. This protein family has attracted attention in recent years after SV2A was …
SV2B, and SV2C. This protein family has attracted attention in recent years after SV2A was …