The amyloid precursor protein (APP) has previously been allocated to an organellar pool
residing in the Golgi apparatus and in endosomal compartments, and in its mature form to a …

Background It is becoming increasingly evident that deficits in the cortex and hippocampus
at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic …

This manuscript presents a thorough review of synaptic vesicle glycoprotein 2A (SV2A) as a
biomarker for synaptic integrity using Positron Emission Tomography (PET) in …

INTRODUCTION Extracellular vesicles (EVs) have been implicated in the spread of
neuropathology in Alzheimer's disease (AD), but their involvement in behavioral outcomes …

The Alzheimer's disease (AD)‐associated ubiquilin‐1 regulates proteasomal degradation of
proteins, including presenilin (PS). PS‐dependent γ‐secretase generates β‐amyloid (Aβ) …

In Alzheimer's disease (AD), tau, a microtubule-associated protein (MAP), becomes
hyperphosphorylated, aggregates, and accumulates in the somato-dendritic compartment of …

Pro-inflammatory protein S100A9 was established as a biomarker of dementia progression
and compared with others such as Aβ1–42 and tau-proteins. CSF samples from 104 …

Abstract Background SV2A, SV2B and SV2C are synaptic vesicle proteins that are
structurally related to members of the major facilitator superfamily (MFS). The function and …

This study reports the solubilization of the rat synaptic vesicle protein SV2A, the brain
binding site for the antiepileptic drug levetiracetam (LEV), and its characterization. N …

The Synaptic Vesicle Protein 2A (SV2A) is a transmembrane protein whose presence is
reduced both in animal models and in patients with chronic epilepsy. Besides its implication …